Severe, sustained pulmonary hypertension leads to pulmonary vascular obstructive disease, which is potentially fatal. But recent advances in genetics and cell biology provide insights into the pathogenesis of this disease and new treatments offer an improved quality of life and increased survival. The field is moving rapidly, and it is time to adopt a more positive and aggressive approach to th...

Cardiac disease is the main cause of death in both forms of thalassemia; thalassemia major (TM) and thalassemia intermedia (TI). Pulmonary hypertension (PH) is one of the cardiopulmonary morbidities with high mortality that, if not treated, may trigger right-sided heart failure and premature death. PH is defined as a mean pulmonary artery pressure of ≥25 mmHg at rest or ≥30 mmHg during exercise...

pulmonary arterial hypertension (pha) is a frequent complication of congenital heart disease (chd), most commonly in systemic-to-pulmonary shunt lesions. in patients with an uncorrected left-to right shunt, pah will end up to eisenmenger’s syndrome, which is contraindication of surgery. what about patients with moderate to severe pah, who do not have criteria of eisenmenger’s syndrome; immediat...

conclusions ipah is associated with subclinical hypothyroidism and low patient functional capacity, and is more common in rv failure. results in this research, 84.8% of the participants were women. the mean pap was 51.6 mmhg (31-87) and mean thyroid stimulating hormone (tsh) level was 4.2 miu/ml (0.7 - 10). subclinical hypothyroidism was detected in 26 patients (49.1%). there were significant c...