2009;72;1540-1541; originally published online Feb 25, 2009; Neurology Stephen C. Cannon Getting a charge out of periodic paralysis? This information is current as of May 4, 2009 http://www.neurology.org/cgi/content/full/72/18/1540 located on the World Wide Web at: The online version of this article, along with updated information and services, is All rights reserved. Print ISSN: 0028-3878. Onl...

PURPOSE Presenting the case of unusual onset hypokalemic periodic paralysis (HypoPP) where myopathy had developed two years before paralysis occurred. MATERIAL AND METHODS A Polish three-generation family with HypoPP and mutation in CACNA1S (R1239G) has been investigated. Clinical presentation with unusual onset of the disease, biopsy results and genetic research in one family member were des...

CONTEXT The aim of this article was to review the clinical presentation, pathogenesis, and management of thyrotoxic periodic paralysis (TPP). EVIDENCE ACQUISITION A MEDLINE search was conducted for articles published during the last 40 yr based on the key words thyrotoxic periodic paralysis and hypokalemic periodic paralysis. A total of 281 primary articles and 168 references of the retrieved...

Hypokalemic periodic paralysis is a rare and dramatic complication of hyperthyroidism. This series summarizes the clinical and metabolic features of 10 patients who presented to the Western and Sunshine hospitals in Melbourne, Australia, between 1997 and 2002 with thyrotoxic periodic paralysis (TPP). TPP classically presents with proximal lower-limb weakness in the setting of a low potassium le...

Periodic paralysis, idiopathic atrial fibrillation, acropachy, manic depressive illness, skeletal manifestations, pernicious anaemia and pre-tibial myxoedema have all been separately reported in association with thyrotoxicosis. It is very unusual to encounter a patient with many of the complications. In Singapore thyrotoxic periodic paralysis is relatively common (6.0% of all thyrotoxics) while...

Although serum potassium levels are usually subnormal in Thyrotoxic Periodic Paralysis (TPP), but in exceptionally rare circumstances, it may be normal leading to the entity called normokalemic TPP. The diagnosis of normokalemic TPP is more often overlooked and/or delayed due to lack of awareness among the physicians and associated mild symptoms of hyperthyroidism. Here, the author describes th...

Objective. Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of Graves' disease (GD). The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP. Methods. Sixteen patients with GD/TPP were followed over a 14-year period. ATD was generally prescribed upfront for 12-18 months before RAI or surgery ...

BACKGROUND Thyrotoxic periodic paralysis (TPP) is a life-threatening channelopathy manifesting as recurrent episodes of hypokalemia and muscle weakness in the presence of hyperthyroidism. Recent findings indicate defects of inward rectifying K+ (Kir) channels are associated with some TPP patients. The associations are not only found in Caucasian population (mainly Brazilian), but also in Singap...

Sah, Rajan L., Robert G. Tsushima, and Peter H. Backx. Effects of local anesthetics on Na1 channels containing the equine hyperkalemic periodic paralysis mutation. Am. J. Physiol. 275 (Cell Physiol. 44): C389–C400, 1998.—We examined the ability of local anesthetics to correct altered inactivation properties of rat skeletal muscle Na1 channels containing the equine hyperkalemic periodic paralysi...

Aims. To report outcomes of the simultaneous surgical correction of vertical rectus paralysis combined with moderate-to-large angle horizontal strabismus. Methods. If a preoperative forced duction test was positive, antagonist muscle weakening surgery was performed, and then augmented partial rectus muscle transposition (APRMT) + partial horizontal rectus recession-resection was performed 2 mon...