Chemotherapy-induced peripheral neuropathies (CIPNs) are an increasingly common neuropathic and pain syndrome in adult and pediatric cancer patients and survivors [1-69]. However, symptoms associated with CIPNs are often undiagnosed, under-assessed, and communications problems between clinicians, family members, and patients have been observed [70-73]. Less is known about the prevalence and imp...

Clinical trials specifically tailored to the unique tumors and leukemias of children have resulted in increased survival rates approaching or exceeding 70% for most diseases. These studies have been carried out by investigators at large, independent institutions or through the auspices of the Children's Cancer Group or Pediatric Oncology Group. The National Cancer Institute has also supported p...

PURPOSE OF REVIEW Many children with cancer suffer from neuropathic pain. However, there are no published pediatric randomized controlled trials (RCTs), nor agreed upon pediatric treatment recommendations. Pediatric neuropathic pain in patients with malignancies is often underassessed and undertreated with ineffective therapies. RECENT FINDINGS This article describes main themes in the litera...

OBJECTIVE To determine histology, staging, and survival for pediatric sinus cancer. METHODS Cases of pediatric sinus cancer (maxillary, ethmoid, and frontal/sphenoid) were extracted from the Surveillance, Epidemiology, and End Results database (1988-2005). Demographic data were tabulated and non-lymphoid malignancies were staged according to the TNM system. Kaplan-Meier survival analyses were...

BACKGROUND For many childhood cancer survivors follow-up care is important long after treatment completion. We aimed to describe the availability and characteristics of long-term follow-up programs (LTFU) across Europe, their content and aims, their problems, and to assess opinions on different models of LTFU. METHODOLOGY/PRINCIPAL FINDINGS We asked 179 pediatric oncology institutions in 20 E...

PURPOSE AND EXPERIMENTAL DESIGN The role of RASSF1A has been elucidated recently in regulating apoptosis and cell cycle progression by inhibiting cyclin D1 accumulation. Aberrant RASSF1A promoter methylation has been found frequently in multiple adult cancer types. Using methylation-specific PCR and reverse transcription-PCR, we investigated epigenetic deregulation of RASSF1A in primary tumors,...

Acupuncture is infrequently studied in the pediatric oncology population; however, it has immense potential as a complementary cancer care modality. The aim of our analysis was to characterize the patients and utilization of acupuncture therapy among the pediatric oncology population at a tertiary care pediatric hospital. A retrospective analysis of medical records for patients between the ages...

ABSTRACT Pediatric early warning system (PEWS) can be an detection of worsening in pediatric patients with chronic diseases, quantitative studies related to the implementation PEWS children diseases have been carried out various countries including USA, Guatemala and China. The purpose this review is determine diseases. This literature study uses a method approach, data sources through Proquest...

PURPOSE Adult cancer is frequently preceded by a period of prolonged chronic inflammation caused by infectious microbial agents or physical or chemical irritants. By contrast, an association between the classic pediatric neoplasias and inflammatory triggers is only rarely recognized. We hypothesized that the difference could be reflected in the inflammatory cell infiltrates of pediatric and adu...