نتایج جستجو برای: pde3a
تعداد نتایج: 120 فیلتر نتایج به سال:
Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury.
Although inhibition of cyclic nucleotide phosphodiesterase type 3 (PDE3) has been reported to protect rodent heart against ischemia/reperfusion (I/R) injury, neither the specific PDE3 isoform involved nor the underlying mechanisms have been identified. Targeted disruption of PDE3 subfamily B (PDE3B), but not of PDE3 subfamily A (PDE3A), protected mouse heart from I/R injury in vivo and in vitro...
Local cyclic adenosine monophosphate signalling cascades—Roles and targets in chronic kidney disease
The molecular mechanisms underlying chronic kidney disease (CKD) are poorly understood and treatment options limited, a situation underpinning the need for elucidating causative identifying innovative options. It is emerging that cyclic 3′,5′-adenosine monophosphate (cAMP) signalling occurs in defined cellular compartments within nanometre dimensions processes whose dysregulation associated wit...
We hypothesized that decreases in expression and/or activity of cAMP-specific phosphodiesterases (PDE) contribute to protective adaptations observed in lung after heart failure. In this study, we compared PDE activity in lung parenchyma isolated from control dogs and those paced to heart failure by assaying cyclic nucleotide hydrolysis in fractions of homogenate supernatant eluted from DEAE-Tri...
Melanoma, arising from the malignant transformation of melanocytes, is one deadliest cancers. With advances in targeted therapy and immunotherapy, prognosis metastatic melanoma has improved.1 However, there an ongoing need to make further progress treatment melanoma. A substantial number patients receiving immunotherapy eventually developed resistance, which contributed by highly heterogeneous ...
Colon cancer is a malignancy that develops in colon and rectal tissues. The prognosis for metastatic colon cancer remains poor, and novel therapeutic options are required to reduce colon cancer mortality. Recently, intracellular cAMP levels have been suggested to influence the behavior of cancer cells. Intriguingly, cyclic phosphatidic acid (cPA) and its structural analogs inhibit growth in man...
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