OBJECTIVES Prevalence of opioid addiction has alarmingly increased over the recent years. In South Asian region alone there are more than 10 million opioid abusers amounting to 2% of world population. Detoxification remains to be the first step for the successful treatment of opioid addiction. The present study was carried out to compare the relative efficacy and safety of buprenorphine -naloxo...

Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma stem cells might be the main reason why conventional therapies fail. The second messenger cyclic AMP (cAMP) controls cell proliferation, differentiation, and apoptosis. Downregulation of cAMP sensitizes tumor cells for an...

Abstract Injection-related infections require prolonged antibiotic therapy. Outpatient parenteral antimicrobial therapy (OPAT) has been shown to be feasible for people who inject drugs (PWID) in some settings. We report a national survey on practice patterns and attitudes of infectious diseases (ID) clinicians the U.S. regarding use OPAT PWID.

BACKGROUND Opioids are widely prescribed for their analgesic properties. Chronic opioid use is a persistent problem in the US. Nevertheless, little is known about its prescribing and utilization patterns and overall expenditures. OBJECTIVE This study examined secular trends in opioid prescription drug utilization and expenditures, along with factors associated with opioid prescription drug us...

The US Opioid Epidemic has been a serious continuous threat to Americans since the early 2000s. "More than 932,000 people have died 1999 from drug overdose. Nearly 75% of overdose deaths in 2020 involved an opioid" (CDC, 2022). Prescription opioids are highly addictive and commonly prescribed treat moderate, severe, or chronic pain. Chronic pain is multidimensional experience that encompasses b...

Initiation of therapy with strong opioids is a challenging phase to obtain the maximum benefit and to gain the patient's compliance. The approach could be different, depending on the clinical situation and type of opioid regimen. Substantially, the need to titrate the dose of strong opioids emerges in different conditions: (a) in opioid-naive patients who require an opioid treatment; (b) in pat...

1. The pharmacological modulation of opioid actions by drugs acting on heterologous mechanisms could be useful to overcome some of the main problems associated with the use of opiate agonists. Based on previous findings on the interactions between yohimbine and opioid drugs, we have further studied the effects of yohimbine on the antinociceptive and positive-negative reinforcing effects of morp...

Opioid intoxications and overdose are associated with high rates of morbidity and mortality. Opioid overdose may occur in the setting of intravenous or intranasal heroin use, illicit use of diverted opioid medications, intentional or accidental misuse of prescription pain medications, or iatrogenic overdose. In this review, we focused on the epidemiology of illict opioid use in the United State...

Perspectives An estimated 6.5 to 13.2 million people with opioid dependence, representing more than half of the world's estimated number, live in Asia. 1 Although most people in Asia who are opioid dependent use heroin or opium, the use of pharmaceutical opioids, mainly through the injecting route, has raised concern in recent years. and Sri Lanka – the estimated number of people who inject dru...

CONTEXT Whether epidural analgesia is a better method than parenteral opioids for postoperative pain control remains controversial. OBJECTIVE To systematically review the efficacy of postoperative epidural analgesia vs parenteral opioids, the primary alternative technique. DATA SOURCES Studies were identified primarily by searching the National Library of Medicine's PubMed database (1966 to...