Objective: To compare the flow of the left internal thoracic artery under a local pharmacological effect caused by the topical action on the arterial pedicle and the intraluminal effect of a calcium channel blocker with a control group using papaverine. Methods: Over a period from July to November 2004, a prospective study was performed involving 73 patients who were submitted to coronary arter...

Benzylisoquinoline alkaloids are a diverse class of plant specialized metabolites that includes the analgesic morphine, the antimicrobials sanguinarine and berberine, and the vasodilator papaverine. The two-electron oxidation of dihydrosanguinarine catalyzed by dihydrobenzophenanthridine oxidase (DBOX) is the final step in sanguinarine biosynthesis. The formation of the fully conjugated ring sy...

To determine the role of endothelium-mediated flow-dependent coronary dilatation in humans, we studied the coronary dilatation exerted by maximal pharmacologic increase of coronary flow in 14 patients with normal coronary arteries. Biplane views of the circumflex (Cx) and left anterior descending (LAD) coronary arteries were obtained before and 80 seconds after inducing a maximal increase in fl...

BACKGROUND Neurologic injury is a rare yet devastating outcome of coronary artery bypass grafting surgery. Mechanisms producing both focal and global neurologic injuries include embolization, cerebral hypoperfusion, and hypotension. In this present study, we report an association between variations in the treatment of the internal mammary artery with the detection of cerebral embolic signals. ...

Cerebral blood flow (CBF) and its response to hypercapnia were evaluated in cats with brainstem transected either at rostropontine (pretrigeminal preparation) or prepontine (cerveau isole preparation) level. Additionally, the effect of pentobarbital on CBF response to hypercapnia and to papaverine were examined. CBF was measured with 133 Xe intracarotid injection method. Cortical EEG activity w...

Impotence is syndrome involving the interaction of psychogenic, hormonal, neurological, arterial, venous & sinusoidal factors. Management of impotence has evolved from a time-born pattern of sympathetic discussion and empiric use of medication to a scientifically planned diagnostic protocol and specific treatment regime. The present study was undertaken to assess the effects of pharmacologicall...

The individual contributions of, and potential interactions between, the renin-angiotensin system (RAS) and the humoral adrenergic stress response to blood pressure regulation were examined in rainbow trout. Intravenous injection of the smooth muscle relaxant, papaverine (10 mg/kg), elicited a transient decrease in dorsal aortic blood pressure (PDA) and systemic vascular resistance (RS), and si...

Renal failure is common in heart failure due to renovascular constriction and hypotension. We tested whether selective pharmacological renal artery vasodilation and active renal artery perfusion (ARP) could improve renal function without adverse effects on systemic blood pressure in a canine model of acute heart failure (AHF). AHF was induced by coronary microembolization in 16 adult mongrel do...