References A 67-year-old woman was admitted to hospital because of progressive confusion and perseveration. Her medical history included bipolar disorder, arterial hypertension and gastritis. Her drug therapy on admission was chlorpromazine (Prazine), sertaline (Zoloft), fluphenazine (Moditen), lisinopril (Laaven) and pantoprazole (Controloc). On physical examination the patient appeared euvole...

А im: to analyze the main pharmacokinetic properties of proton pump inhibitors (PPIs) and their significance in treatment gastroesophageal reflux disease (GERD). Key points. Pantoprazole has a high bioavailability, absolute bioavailability pantoprazole at dose 40 mg is 77 % from first does not change with repeated use. shows faster onset action than omeprazole. Simultaneous food intake pantopra...

Recent studies report an increased risk of enteric infections in patients treated with proton pump inhibitors (PPIs). Polymorphonuclear neutrophils (PMNs) play a key role in host response to bacterial infection. We evaluated the effect of omeprazole and pantoprazole treatment on the PMN function. Fifteen patients were treated with omeprazole 20 mg daily and 15 patients with pantoprazole 40 mg d...

OBJECTIVES Pantoprazole, is a proton pump inhibitor (PPI) prescribed for the treatment of upper gastrointestinal disorders, which in high doses has been suggested to decrease calcium absorption leading to hypocalcaemia and therefore osteoporosis. The aim of this study was to assess whether pantoprazol, could alter the rate of orthodontic tooth movement (OTM) in rats. MATERIALS AND METHODS A t...

The impact of the CYP2C19*17 allele on the pharmacokinetics of pantoprazole and omeprazole in previously studied children (n = 40) was explored. When pantoprazole area under the plasma concentration versus time curve (AUC) was examined as a function of CYP2C19 genotype, a significantly lower AUC was observed for subjects identified as CYP2C19*1/*1 and *1/*17. For pantoprazole, a statistically s...

BACKGROUND Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA). Proton pump inhibitors impair exposure to MPA due to incomplete conversion from MMF. Lower exposure to MPA could result in an increased risk of acute rejection. We investigated whether MMF-treated renal transplant patients who concomitantly used pantoprazole as ulcer prophylaxis had a higher risk of acute rejectio...

Proton pump inhibitors (PPIs) have been known to cause bradycardia. We evaluated the effect of three PPIs, i.e. omeprazole, rabeprazole and pantoprazole on the heart rate of frog. The in situ frog heart preparation was set up. Heart rate and amplitude of contraction were studied following administration of different doses of the three PPIs. Statistical analysis was done by using Graphpad statis...

background : proton pump inhibitors (ppis) are currently the most effective agents for acid related disorders. however, studies show that 25-75% of patients receiving intravenous pantoprazole had no appropriate justification, indicating high rate of inappropriate prescribing in hospitals. the aim of this study is to examine the appropriate use of intravenous pantoprazole in accordance with guid...

BACKGROUND Drug use evaluation is a performance improvement method that evaluates medication-use processes. Medication studies are especially important for drugs with narrow therapeutic index, specific indication, high costs as well as for drugs with widespread use. Intravenous pantoprazole always ranked among the top 5 costly drugs in Amir-al-Momenin Hospital. Considering the fact that widespr...

BACKGROUND/AIMS To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms. METHODS Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a ...