Acinar cell pancreatic carcinoma is a rare solid malignant neoplasm. Recent review of the literature showed occasional cases with papillary or papillocystic growth patterns, ranging from 2 to 5 cm in diameter. We report a large 10 cm pancreatic tumor with papillocystic pathology features involving the pancreatic head. The growth pattern of these tumors could be mistaken for intraductal papillar...

Several important characteristics of exocrine pancreatic tumor pathogenesis remain incompletely defined, including identification of the cell of origin. Most human pancreatic neoplasms are ductal adenocarcinomas. However, acinar cells have been proposed as the source of some ductal neoplasms through a process of acinar-to-ductal metaplasia. The oncogenic transcription factor c-myc is associated...

Our previous studies in zebrafish development have led to identification of the novel roles of the transient receptor potential melastatin-subfamily member 7 (TRPM7) ion channels in human pancreatic cancer. However, the biological significance of TRPM7 channels in pancreatic neoplasms was mostly unexplored. In this study, we determined the expression levels of TRPM7 in pancreatic tissue microar...

BACKGROUND/AIMS It was recently reported that the quantitative analysis of mutant K-ras gene in pancreatic juice could be useful for the diagnosis of pancreatic cancer. This methodology was applied to patients with pancreatic cystic lesions. METHODS DNA was extracted from pancreatic juice collected at the time of endoscopy with injection of secretin. The ratio of the K-ras mutant allele to th...

The cellular origin of pancreatic tumors remains a vital topic for research to further our understanding of carcinogenesis. We currently do not know if cellular origin determines the phenotype of pancreatic tumors. Ninety percent of newly diagnosed pancreatic cancers are ductal adenocarcinomas (PDA). The majority of PDA are thought to originate from low-grade precursor tumors termed pancreatic ...

Diagnostic accuracy in regard to biliary and pancreatic diseases has improved markedly since the introduction of computed tomography (CT) and magnetic resonance cholangiopancreatography (MRCP)(1,2), but detection of small bile duct cancers and small pancreatic cancers is difficult even by those modalities. Endoscopic retrograde cholangiopancreatography (ERCP) remains the most accurate and relia...

Solitary metastatic pancreatic lesions comprise 0.5% to 3% of all pancreas neoplasms, most commonly arising from primary tumors of the kidney, lung, or colon. Synchronous metastatic pancreatic lesions are exceptionally rare. Only 25 cases of isolated colorectal pancreatic metastasis amenable to resection have been reported, 11 of those in the distal pancreas. To our knowledge we report the firs...

tive patients which implies education and integration of general practitioners, community hospitals, and tertiary referral centers specialized in pancreatic disease. Regardless of the individual management decision to act on a newly diagnosed cystic neoplasm, significant costs for the health care system may be associated – by lifelong surveillance as well as by surgery and potential additional ...

The high mobility group I (HMGI) family of proteins in mammals belongs to a group of nonhistone nuclear proteins known as architectural transcriptional factors. They function in vivo as both structural components of chromatin and auxiliary gene transcription factors. In an earlier study (N. Abe et al, Cancer Res., 59: 1169-1174, 1999), we demonstrated that the expression level of the HMGI(Y) ge...

Background: The most common types of true epithelial exocrine pancreatic cystic neoplasms are serous (SCNs), mucinous (MCNs), intra-ductal papillary (IPMNs), and solid pseudo-papillary (SPPNs). Both open laparoscopic surgeries major procedures with significant morbidity mortality rates. This study aimed to determine the outcomes surgery in managing terms postoperative fistula recurrence rate id...