نتایج جستجو برای: nonsteroidal antiflammatory drugs nsaids
تعداد نتایج: 228374 فیلتر نتایج به سال:
BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are a standard treatment for osteoarthritis (OA), but the use of oral NSAIDs has been linked to an elevated risk for cardiovascular and gastrointestinal adverse events and renal toxicity. Topical NSAIDs are thought to afford efficacy that is comparable to oral formulations while reducing widespread systemic drug exposure, which may provid...
BACKGROUND/OBJECTIVE Anti-inflammatory drugs may prevent Parkinson disease (PD) by inhibiting a putative underlying neuroinflammatory process. We tested the hypothesis that anti-inflammatory drugs reduce PD incidence and that there are differential effects by type of anti-inflammatory, duration of use, or intensity of use. METHODS MEDLINE and EMBASE were searched for studies that reported ris...
Direct gastric mucosal cell damage mediated by nonsteroidal anti-inflammatory drugs (NSAIDs) is involved in the formation of NSAID-induced gastric lesions. We recently suggested that this direct cytotoxicity of NSAIDs is caused by their membrane-permeabilization activity. Geranylgeranylacetone (GGA), a clinically used antiulcer drug, can protect gastric mucosa against lesion formation mediated ...
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group, are reported safer than NSAIDS: To assess their potential in colon cancer chemoprevention, we studied in vitro the effect of NO-aspirin, NO-sulindac, and NO-ibuprofen on colonocyte kinetics. These three NO-NSAIDs redu...
Submit Manuscript | http://medcraveonline.com Abbreviations: CIN: Contrast-Induced Nephropathy; CIAKI: Contrast-Induced AKI; CKD: Chronic Kidney Disease; Cr: Creatinine; GFR: Glomerular Filtration Ratio; NSF: Nephrogenic Systemic Fibrosis; AMI: ACUTE Myocardial Infarction; NSAIDs: Nonsteroidal Anti-Inflammatory Drugs; AKI: Acute Kidney Injury; ATN: Acute Tubular Necrosis; TIN: Tubulointerstitia...
Submit Manuscript | http://medcraveonline.com Abbreviations: CIN: Contrast-Induced Nephropathy; CIAKI: Contrast-Induced AKI; CKD: Chronic Kidney Disease; Cr: Creatinine; GFR: Glomerular Filtration Ratio; NSF: Nephrogenic Systemic Fibrosis; AMI: ACUTE Myocardial Infarction; NSAIDs: Nonsteroidal Anti-Inflammatory Drugs; AKI: Acute Kidney Injury; ATN: Acute Tubular Necrosis; TIN: Tubulointerstitia...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifeste...
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