In the course of studies of t.he reduction of Furacin (5-nitro-2-furaldehyde semicarbazone) by cell-free extracts of a strain of Escherichia co& the presence of a number of diphosphopyridine nucleotide-linked dehydrogenases was indicated by the ability of such extract’s when dialyzed to reduce the nitrofuran only on the addition of diphosphopyridine nucleotide (DPN) and any one of a number of o...

Mycobacterium tuberculosis dosRS two-component regulatory system controls transcription of approximately 50 genes including hspX, acg and Rv2030c, in response to hypoxia and nitric oxide conditions and within macrophages and mice. The hspX lies between acg and Rv2030c. However, the functions of the dosR regulated genes in vitro and in vivo are largely unknown. Previously, we demonstrated that d...

The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB bacilli. In previous studies, the pharmacokinetic properties of nitrofuranyl isoxazolines were improved by incorporation of the outer ring elements of ...

Antibodies have widely been used as analytical tools in various assays and techniques developed for clinical chemistry and endocrinology and for food and environmental research and risk control. Antibody development in the Veterinary Research Institute, Brno, and their application in ELISA and related techniques such as immunosensors has been directed especially to phenoxyacetic acid herbicides...

Furazolidone and nitrofurantoin, oral nitrofuran derivatives with broad-spectrum antimicrobial properties already in clinical use, were compared for activity against Pneumocystis carinii in an immunosuppressed rat model of P. carinii pneumonia. Furazolidone exhibited only slight activity as a prophylactic agent but was moderately effective in the therapy of pneumocystosis. The median histologic...

Introduction: Escherichia coli (E. coli) is one of the main bacterial species associated with urinary tract infections. Nowadays, this bacterium becoming more and resistant to antibiotics. Objective: The aim study was determine antibiotic sensitivity profiles all strains E. isolated from urine during period September 1st, 2018 March 13th, 2019 at Biomedical Laboratory China-Guinea Friendship Ho...