BACKGROUND Glucose is a major oxidative substrate for intestinal energy generation in neonatal animals; however, few data in preterm infants are available. Early administration of enteral nutrition, including glucose, may be an effective strategy to support intestinal adaptation to extrauterine life in preterm neonates. OBJECTIVE The purpose of the present study was to quantify the first-pass...

We used retrogradely transported fluorescent tracers to study the development of projections from area 17 to area 18 in normal and monocularly deprived kittens. In newborn animals, cells in area 17 that were labeled from small, discrete injections in area 18 were concentrated around the retinotopically corresponding zone, but distributed with lower density over a very wide surrounding area. Hen...

To determine the effect of benzo[a]pyrene (B[a]P) on the developing immune system of immature rats, newborn animals received different concentrations (0.1, 1.0 and 10.0 mg/kg/day) of B[a]P in the first 14 days after birth. These rats were euthanised on day 23 of the experiment and it was found that the decreasing numbers of erythrocytes were in direct correlation to the dose of B[a]P. In subjec...

Our data indicate the significant intrinsic efficacy of GABA(B)-receptors in rat brain cortex already at birth (PD1, PD2). Subsequently, baclofen- and SKF97541-stimulated G-protein activity, measured by agonist-stimulated, high-affinity [(35)S]GTPgammaS binding assay, was increased; the highest level of both baclofen and SKF97541-stimulated [(35)S]GTPgammaS binding was detected between PD10 and...

It has been established that topical glucocorticoids, widely used for dermatological treatments, have a high rate of transcutaneous penetration and once absorbed into systemic circulation they produce unwanted secondary systemic side effects. As resulted from our preliminary experiments a short-term epicutaneous treatment with Fluocinolonacetonid N in various age groups of rats induces structur...

Exposure of newborn animals to a foreign Ag may result in immunological tolerance to that specific Ag, a phenomenon called neonatal tolerance. We have previously reported that neonatal administration to Brown-Norway rats of mercury, a heavy metal toxicant, induces a dominant tolerance, specific for the chemical otherwise responsible for Th2 cell-mediated autoimmune responses in this susceptible...

The balance of platelet and vascular functions clearly determines the functioning primary hemostasis in piglet’s body. This is particular physiological importance at beginning piglet ontogenesis. degree functional readiness platelets blood vessels piglets during neonatal period state microcirculation tissues activity many mechanisms this stage development. disaggregation properties vessels, whi...

Newborn hamsters were inoculated either i.p. or s.c. with 0.1 to 0.2 ml of CELO. Random-bred (19) and inbred LSH/LAK (8) hamsters from our colony were used. The inoculated animals were weaned and sex segregated at 3 weeks of age. The hamsters were observed until death. Animals were sacrificed by cardiac puncture. Ascitic fluids were collected from the peritoneal cavity by syringe. In general, s...

The efficacy of interferon in antiviral protection of newborn mice differing at the Mx locus was investigated. Adult mice bearing the allele Mx exhibit a high degree of specific resistance toward lethal challenge with influenza viruses. In contrast, newborn Mx carriers are virtually as susceptible to influenza viruses as newborn mice devoid of Mx. Resistance can be abrogated by treating adult a...

Newborn Yorkshire and Ossabaw (feral) pigs were examined under thermoneutral conditions to determine whether survival rate during fasting differs between these breeds and whether any blood-borne factors are associated with improved survival. Newborn pigs were removed from the sow before suckling. Body composition was determined on 10 newborn Ossabaw and 12 newborn Yorkshire pigs. Another group ...