نتایج جستجو برای: msi

تعداد نتایج: 3019  

2012
Nicole A. Siddall Marina Kalcina Timothy M. Johanson Adrian C. Monk Franca Casagranda Reeva P. Been Eileen A. McLaughlin Gary R. Hime

The vertebrate RNA-binding proteins, Musashi-1 (Msi-1) and Musashi-2 (Msi-2) are expressed in multiple stem cell populations. A role for Musashi proteins in preventing stem cell differentiation has been suggested from genetic analysis of the Drosophila family member, dMsi, and both vertebrate Msi proteins function co-operatively to regulate neural stem cell behaviour. Here we have identified a ...

2013
Da-Wei Yao Jia-Rong Xu Zhen-Lei Zhou Shang-Tong Li De-Ji Yang

Microsatellite instability (MSI) has been found in a range of human tumors, and little is known of the links between MSI and herpesvirus. In order to investigate the relationship between MSI and Gallid herpesvirus 2 (GaHV-2)-induced lymphoma, fifteen Marek's disease (MD) lymphomas were analyzed through using 46 microsatellite markers, which were amplified by PCR from DNA specimens of lymphoma a...

Journal: :Genetics and molecular research : GMR 2013
L N R Alves E V Wolfgramm A K de Castro Neto I D Louro

Ovarian cancer is currently the most lethal gynecological malignancy in women. It is a heterogeneous and cytogenetically complex disease previously associated with genomic instability. Our purpose was to analyze microsatellite markers to determine patterns and levels of instability as well as possible correlations with histopathological parameters. Polymerase chain reaction was used to characte...

Journal: :Anticancer research 2004
Arifumi Hasegawa Toshihiko Fukushima Miyuki Mashiko Keiichi Nakano Satoshi Suzuki Yoshiyuki Endo Shinji Ohki Yuichi Hatakeyama Yoshihisa Koyama Norio Inoue Yuji Takebayashi Kouji Sekikawa Sei-ichi Takenoshita

BACKGROUND The international guidelines for the evaluation of microsatellite instability (MSI) in colorectal cancer were defined in 1997 by the National Cancer Institute (NCI). Here, the relationship between MSI, cancer-associated genes and their clinicopathological variables were revaluated using these guidelines. PATIENTS AND METHODS Mutations of K-ras at exon 1 and p53 at exons 5, 6, 7 and...

2014
John M. Carethers Bhavya Murali Bing Yang Ryan T. Doctolero Akihiro Tajima Ranor Basa E. Julieta Smith Monte Lee Ryan Janke Tina Ngo Ruth Tejada Ming Ji Matthew Kinseth Betty L. Cabrera Katsumi Miyai Temitope O. Keku Christopher F. Martin Joseph A. Galanko Robert S. Sandler Kathleen L. McGuire

African American patients with colorectal cancer show higher mortality than their Caucasian counterparts. Biology might play a partial role, and prior studies suggest a higher prevalence for microsatellite instability (MSI) among cancers from African Americans, albeit patients with MSI cancers have improved survival over patients with non-MSI cancers, counter to the outcome observed for African...

2015
Daiva Kanopiene Jolanta Vidugiriene Konstantinas Povilas Valuckas Giedre Smailyte Saule Uleckiene Jeff Bacher

Microsatellite instability (MSI) is an important factor in the development of various cancers as an identifier of a defective DNA mismatch repair system. The objective of our study was to define the association between microsatellite instability status and traditional clinicopathologic characteristics of endometrioid type adenocarcinoma. MATERIAL AND METHODS MSI status of endometrial cancer w...

Journal: :The American journal of surgical pathology 2009
Petra Ruemmele Wolfgang Dietmaier Luigi Terracciano Luigi Tornillo Frauke Bataille Annette Kaiser Peter-Heinz Wuensch Ernst Heinmoeller Kia Homayounfar Jutta Luettges Guenter Kloeppel Fausto Sessa Tina Bocker Edmonston Regine Schneider-Stock Monika Klinkhammer-Schalke Armin Pauer Stefan Schick Ferdinand Hofstaedter Daniel Baumhoer Arndt Hartmann

The prevalence and development of microsatellite instability (MSI) and underlying mismatch repair (MMR) deficiency in the carcinogenesis of adenocarcinomas of the papilla of Vater and their precursor lesions are not well established. We analyzed 120 ampullary adenomas (31 pure adenomas and 89 carcinoma-associated adenomas) and 170 pure adenocarcinomas for MSI, immunohistochemical expression of ...

2015
Jeffery W. Bacher Chelsie K. Sievers Dawn M. Albrecht Ian C. Grimes Jennifer M. Weiss Kristina A. Matkowskyj Rashmi M. Agni Irina Vyazunova Linda Clipson Douglas R. Storts Andrew T. Thliveris Richard B. Halberg Michela Grosso

Microsatellite instability (MSI) occurs in over 90% of Lynch syndrome cancers and is considered a hallmark of the disease. MSI is an early event in colon tumor development, but screening polyps for MSI remains controversial because of reduced sensitivity compared to more advanced neoplasms. To increase sensitivity, we investigated the use of a novel type of marker consisting of long mononucleot...

Journal: :Oncology reports 2008
Zhang Huan Kentaro Nakayama Naomi Nakayama Masako Ishibashi Shamima Yeasmin Atsuko Katagiri Indri Nuryani Purwana Kouji Iida Riruke Maruyama Manabu Fukumoto Kohji Miyazaki

Ovarian carcinomas can progress through two pathways of genomic instability: chromosomal instability (CIN) and microsatellite instability (MSI). However, it is unknown whether these two mechanisms could be distinguished from each other in the molecular characteristics in ovarian carcinomas. We hypothesized that these two pathways are not always independent in ovarian carcinomas. We classified 5...

Journal: :Oncology 2004
Ramon Martinez Hans-K Schackert Jens Plaschke Gustavo Baretton Hella Appelt Gabriele Schackert

OBJECTIVE Two chromosomal instability (CIN) pathways are described in glioblastoma multiforme (GBM), type 1 and type 2, which can be observed in up to 70% of the cases. Microsatellite instability (MSI) plays a pathogenic role in sporadic cancers such as colon, gastric and endometrial carcinomas with deficient mismatch repair (MMR). We aimed to perform a comprehensive analysis of the relationshi...

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