نتایج جستجو برای: morphine analgesia formalin test rat

تعداد نتایج: 1112371  

Journal: :physiology and pharmacology 0
leila ahmad-molaei mehdi ordikhani-seyedlar maryam ziaei raha khademi pegah rouzmeh abbas haghparast

introduction: the antinociceptive effect of morphine is, in part, mediated through the activation of a descending pathway. one of the major components of this pathway is the nucleus raphe magnus (nrm). our previous study demonstrated the involvement of nrm in the analgesic effect of morphine microinjected into the nucleus cuneiformis (ncf) in a descending manner. the aim of the current study wa...

This study investigates the effectiveness of the antinociceptive effects of diclofenac, an NSAID, on the nociceptive behavior of morphine-treated rats on formalin test.Rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. The antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distil...

This study investigates the effectiveness of the antinociceptive effects of diclofenac, an NSAID, on the nociceptive behavior of morphine-treated rats on formalin test.Rats were treated with morphine-containing drinking water for twenty one days, which induced morphine dependence. The antinociceptive effects of 8, 16, and 32 mg/kg doses of diclofenac were then evaluated and compared with distil...

Journal: :basic and clinical neuroscience 0
nematollah gheibi mohammadreza saroukhani hassan azhdari-zarmehri

introduction: the concentration of noradrenalin and corticosterone as the two nociception modulators change after fasting or stress situation. the aim of present study was to investigate the effect of food deprivation on formalin-induced nociceptive behaviours and plasma levels of noradrenalin and corticosterone in rats. methods: food was withdrawn 12, 24 and 48 h prior to performing the formal...

Journal: :Pakistan journal of pharmaceutical sciences 2010
Gholamreza Sepehri Vahid Sheibani Afrooz Azarang Ali Shamsizadeh Mohammad Reza Afarinesh Saeed Azizollahi Ehsan Sepehri

The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli w...

Journal: :British journal of pharmacology 1998
J H Tian W Zhang Y Fang W Xu D K Grandy J S Han

1. Our previous work has demonstrated that exogenously administered orphanin FQ (OFQ) antagonizes morphine analgesia and electroacupuncture analgesia (EAA) in the brain and potentiates morphine analgesia and EAA in the spinal cord of the rat. In the present study we evaluated the role of endogenously released OFQ in the development of tolerance to morphine and electroacupuncture (EA) and the an...

Journal: :iranian journal of basic medical sciences 0
ali shamsizadeh physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran neda soliemani physiology-pharmacology research center, rafsanjan university of medical sciences, rafsanjan, iran mohammad mohammad-zadeh department of physiology & pharmacology, cellular and molecular research center, sabzevar university of medical sciences, sabzevar, iran hassan azhdari- department of basic sciences, torbat heydariyeh university of medical sciences, torbat heydariyeh, iran

objective(s): there are many reports about the role of rostral ventromedial medulla (rvm) in modulating stress-induced analgesia (sia). in the previous study we demonstrated that temporal inactivation of rvm by lidocaine potentiated stress-induced analgesia. in this study, we investigated the effect of permanent lesion of the rvm on sia by using formalin test as a model of acute inflammatory pa...

Journal: :physiology and pharmacology 0
farnaz nikbakht neuroscience research center, shaheed beheshti univ. med. sci., tehran, iran zhila behzadi

it has been reported that neurons in the vl pag projecting to nucleus raphe magnus (nrm) utilize excitatory amino acids as neurotransmitter. this projection plays an important role in the descending pain modulatory system. in order to determine the role of this pathway in pain perception, male rats received unilateral injection of ibotenic acid stereotaxically. for lesioning vl pag, unilateral ...

Journal: :basic and clinical neuroscience 0
mohammad reza shahraki zahedan university of medical sciences mahdieh ahmadimoghadm local studies & specialty services of jahad-e-daneshgahi, sistan and baluchistan branch, zahedan, iran. ahmad reza shahraki zahedan university of medical sciences

introduction: borago officinalis flower (borage) is a known sedative in herbal medicine the aim of the present study was to evaluate the antinociceptive effect of borage hydroalcoholic extract in formalin test male rats. methods: fifty-six adult male albino wistar rats were randomly divided into seven groups: control groups of a (intact), b (saline), and c (positive control) plus test groups of...

ارمی, الهه, اژدری‌زرمهری, حسن, حیدری‌اورنجقی, نیما , صالحی, بقیه ا... , صوفی‌آبادی, محمد , قاسمی, المیرا , مهدی‌پور, حبیب ا... ,

  Background and Objectives : Acute and chronic stress induces hormonal and neuronal changes which affect both pain threshold and nociceptive behaviors. But the effect of acute and chronic immobilization stress on formalin induced nociceptive behaviors are unknown. Therefore, this study evaluated the effects of acute and chronic immobilization stress formalin test on the male rat.   Material an...

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