OBJECTIVE The objective of the present study was to explore the significance of human β-defensin 3 (HBD-3) through establishment and evaluation of the model of implant-related biofilm infection of the femoral condyle of the outer knee using Sprague-Dawley (SD) rats. MATERIALS AND METHODS Age-matched SD rats were divided into three groups, the HBD-3 group, HBD-3 fluorescent liposome group, and...

Zhou, Shuyi. M.S.M.E., Purdue University, December 2017. Experimental and Numerical Study on Microbubble Coalescence Dynamics. Major Professor: Likun Zhu. This thesis work aims to make a better knowledge on the insights of physics on microbubble coalescence process, using experimental and numerical approaches. The neck growth and bubble surface wave propagation at the early stage of coalescence...

The cavitation response of circulating microbubbles to targeted ultrasound can be used for noninvasive, site-specific delivery of shell-loaded materials. One challenge for microbubble-mediated delivery of lipophilic compounds is the limitation of drug loading into the microbubble shell, which is commonly a single phospholipid monolayer. In this study, we investigated the use of natural lung sur...

OBJECTIVE To investigate the feasibility of ultrasonographic (US) imaging of head and neck cancer with targeted contrast agents both in vitro and in vivo. We hypothesize that conjugation of microbubble contrast agent to tumor-specific antibodies may improve US detection of head and neck squamous cell carcinoma (HNSCC). DESIGN Preclinical blinded assessment of anti-EGFR and anti-CD147 microbub...

Air bubble detectors (ABDs) are utilized during cardiopulmonary bypass (CPB) to protect against massive air embolism. Stockert (Munich, Germany) ABD quantify microbubbles >300 μm; however, their reliability has not been reported. The aim of this study was to assess the reliability of the microbubble data from the ABD with the SIII and S5 heart-lung machines. Microbubble counts from the ABD with...

Evaluations under way at Thomas Jefferson University are focusing on the use of gas-encapsulated microbubble contrast agents with nonlinear ultrasound imaging techniques to not only detect but also help characterize breast cancer noninvasively. Other recent studies have examined how microbubble contrast agents interact with ultrasound acoustic fields to demonstrate the effectiveness of contrast...

Evaluations under way at Thomas Jefferson University are focusing on the use of gas-encapsulated microbubble contrast agents with nonlinear ultrasound imaging techniques to not only detect but also help characterize breast cancer noninvasively. Other recent studies have examined how microbubble contrast agents interact with ultrasound acoustic fields to demonstrate the effectiveness of contrast...

The self-assembly of gold micropetals and microfluidic control using their photothermal properties are demonstrated experimentally in this work. Gold fabricated on a glass substrate the shadow-sphere lithography technique. Each micropetal consists two areas with thin films different thicknesses resulting an inhomogeneous optical absorption distribution. property results generation water vapor m...

Two thermal challenges for current and next generation microelectromechanical systems (MEMS) applications are discussed. The first topic is the fundamental investigations of phase change phenomena in the microscale. It has been demonstrated that microresistive heaters can generate single, spherical and controllable thermal bubbles with diameters between 2 and 500 mm. Both simplified steady stat...