richard saltman and antonio duran take up the challenging issue of governance in their article “governance, government and the search for new provider models,” and use two case studies of health policy changes in sweden and spain to shed light on the subject. in this commentary, i seek to link their conceptualization of governance, especially its interrelated roles at the macro, meso, and micro...

Standard macro theories reflect a choice-theoretic orientation wherein aggregate variables are treated as acting directly on one another. Macro phenomena are thus reduced to the same order of simplicity as micro phenomena; macro variables differ from micro variables only by their larger size. In contrast, this paper treats the relationship between micro and macro as non-scalable. Macro phenomen...

While it is well established that protonation and tautomeric states of ligands can significantly affect the results of virtual screening, such effects of ionizable residues of protein receptors are less well understood. In this study, we focus on histidine protonation and rotameric states and their impact on virtual screening of Mycobacterium tuberculosis enzyme RmlC. Depending on the net charg...

in the crystal structure of the title polymeric compound, [c42h38n6o33sr5.2(h2o)]n, five independent metal atoms (sr1-sr5) have different coordination environments. the sr1 and sr5 atoms are nine coordinated and feature distorted tricapped trigonal-prismatic and capped square-antiprismatic geometries, respectively. the rest srii atoms have eight coordination numbers. these units are connected v...

government interventions in agricultural markets in order to stabilize commodity prices and producer incomes have had a long tradition. intervention has been at both the state and country levels and has been for the most part in the form of commodity-based schemes. this study represents an attempt to develop an appropriate methodology for analyzing the aggre-gate effects of a particular type of...

The acid-base chemistry of three zwitterionic compounds, namely anthranilic (2-aminobenzoic acid), N-methylanthranilic and N-phenylanthranilic acid has been characterized in terms of the macroconstants Ka1, Ka2, the isoelectric point pHI, the tautomerization constant Kz and microconstants k11, k12, k21, k22. The potentiometric titration method was used to determine the macrodissociation constan...