AMA Adar T, Mizrahi M, Lichtenstein Y, et al. Increased hepatic Akt phosphorylation alleviated glucose intolerance and improved liver function in leptin-deficient mice. Clinical Experimental Hepatology - Manuscripts Accepted. 2023. doi:10.5114/ceh.2023.127849. APA Adar, T., Mizrahi, M., Lichtenstein, Y., Shabat, Sakhnini, R., & Zolotarov, L. (2023). https://doi.org/10.5114/ceh.2023.127849 Chica...

Objective(s) PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and liver samples were obtained. In hyperglycemic rat, 0.5 g/kg glucose with o...

ZnO nanoparticles: Crosslink between cytotoxicity on liver cell lines and In Vivo biosafety different mice organsNahla Nabil Kamel, Maha Zaki Rizk, Walaa Gamal Hozayen, Abdel-Hamid

background nonalcoholic fatty liver disease (nafld) is the most common cause of chronic liver disease in western world. however, nafld shows an increasing trend in china every year, which has attracted the attention of national health authorities. the previous studies have shown that nafld caused severe gastrointestinal motor disorders, but little is known about the interstitial cells of cajal ...

background: trace elements play an important role in a number of biological processes. astaxanthin (asx), a carotoid pigment found in certain marine plant and animals, has shown anti cancer and anti free radical properties. this work intended to understand the effect of astaxanthin in breast cancer (invasive ductal carcinoma, idc) by using micro-pixe method. for this aim the concentration of tr...

ATP binding cassette transporter A1 (ABCA1) limits the formation of high density lipoproteins (HDL) as genetic loss ABCA1 function causes virtual HDL deficiency in patients with Tangier disease. Mice a hepatocyte-specific knockout (Abca1 HSKO) have 20% wild type (WT) plasma HDL-cholesterol levels, suggesting major contribution hepatic to phenotype. Whether sphingolipids are reduced disease and ...

elevated amounts of free radicals due to ionizing radiation have damaging effects on the body. h2-receptor antagonists have potential oxygen radical scavenging properties. we tried to determine the effects of two h2-receptor antagonists (cimetidine and ranitidine) on lipid peroxidation (lpo) and lipid profile (lp) in plasma and liver of γ-irradiated (1gy/day for 3 days) balb/c mice. the control...

Abstract The proper functional interaction between different tissues represents a key component in systemic metabolic control. Indeed, disruption of endocrine inter-tissue communication is hallmark severe dysfunction obesity and diabetes. Here, we show that the FNDC4-GPR116, liver-white adipose tissue axis controls glucose homeostasis. We found liver primarily controlled circulating levels solu...

Abstract Leucine-rich α-2 glycoprotein (LRG), one of the acute phase proteins mainly produced by liver, similar to C-reactive protein, has been recognized as an inflammatory biomarker for rheumatoid arthritis and bowel diseases. We recently demonstrated that LRG was also increased in sera psoriasis patients correlated well with disease activity a sensitivity specificity much higher than protein...

In current study, a few sheep cystic livers and lungs were obtained from Mashhad slaughter house and protoscolex were separated aseptically. Thirty 6-week-old Swiss mice were divided into 5 groups and two thousands of live protoscolices were inoculated intrapritoaneally in each mouse. In group 1 and 2 (prophylactic groups), mice were given 150 mg/kg of oral albendazole and mebendazole for 10 da...