For insulin to act within the brain, it is primarily transported from blood across blood-brain barrier (BBB). However, endocytic machinery necessary for delivering brain remains unknown. Additionally, there are processes endothelial cell that designed respond binding and elicit intracellular signaling. Using pharmacological inhibitors of different types endocytosis (clathrin-vs. caveolin-mediat...

Background: The blood-brain barrier (BBB) is a major hurdle to successful pharmacotherapy of brain tumors. ABCB1 and ABCG2 are efflux transporters that expressed in tumor vessels reduce the uptake many small molecule drugs. Elacridar tariquidar both dual inhibitors. We aim improve cancer by concomitant use potentially effective drugs with elacridar. Since has mostly been used assess effects ABC...

Brain injury is a significant risk factor for chronic gliosis and neurodegenerative diseases. Currently, no treatment available neuroinflammation caused by the action of glial cells following brain injury. In this study, we investigated quinpirole-mediated activation dopamine D2 receptors (D2R) in mouse model traumatic (TBI). We also neuroprotective effects quinpirole (a D2R agonist) against ce...

Background and Objective: Chronic arsenic toxicity is a widespread problem; the role of brain oxidative stress has been suggested in the genesis of epilepsy and in the post-seizure neuronal death. However, studies investigating the effects of arsenic on seizure and related mechanisms are limited. The purpose of this study was to examine the effect of prolonged exposure to sodium arsenite on oxi...

background: development of the central nervous system (cns) is dependent on interactions between genetic and epigenetic factors, some of which could affect the susceptibility of the developing brain to damaging insults. gestational stress has been shown as a potential factor associated with higher risk of developing certain neurological and psychiatric disorders. this study tested the hypothesi...

introduction: astrocytes are the most abundant glial cell type. in addition to their neurological roles, astrocytes also have immune functions. they have been involved in antigen presentation in the central nervous system (cns). activated astrocytes express adhesion molecules, chemokines and release several inflammatory mediators, pro-inflammatory cytokines, neurotrophic and neuroprotective fac...

Introduction: Harmalol is a dihydrocarboline compound found naturally in several alcoholic beverages and medicinal plants. This study was designed to investigate the effect of harmalol on memory function and its possible mechanisms in a scopolamine-induced memory disorder model. Materials and Methods: Thirty five male mice were randomly divided into five (n=7) group: Control group )normal sali...

In the brain, canonical excitatory neurotransmission is mediated by L-glutamate and its ionotropic (iGluR) metabotropic (mGluR) receptors. The wide diversity of these often limits development glutamatergic drugs. This due to arduousness achieving selectivity with specific ligands. present article, encouraged reports bioactive organoboron compounds, a diphenylboroxazolidone derived from quinolin...

how to cite this article: wilson md. animal models of cerebral palsy: hypoxic brain injury in the newborn. iran j child neurol. spring 2015; 9(2):9-16. abstract objective hypoxic insults are implicated in the spectrum of fetal disorders, including cerebral palsy (cp). in view of the major contribution of intrapartum risk factors and prematurity to subsequent neurological morbidity and mortality...

Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal and molecular processes. Technological innovations now allow for parallel investigation of circuit function, structure composition in the brain awake behaving adult mice. Thus, mice have become critical tool to better understand how aging brain. However, more granular systems-based approach, which consi...