Inhaled nitric oxide (iNO) has been shown to have a protective effect in lung ischemia-reperfusion (I/R)-induced injuries. We studied the role of iNO (10 parts/million for 4 h) administered before I/R. In an isolated perfused lung preparation, iNO decreased the extravascular albumin accumulation from 2,059 +/- 522 to 615 +/- 105 microl and prevented the increase in lung wet-to-dry weight ratio....

Sulforaphane (SFN), an antioxidant derived from cruciferous vegetables, exerts antioxidant capacity and protects organ against oxidative damage. However, the effects of SFN on sepsis-induced acute lung injury (ALI) have not been determined. The aim of this study was to investigate the effect of SFN in sepsis-induced ALI and the role of Nrf2/HO-1 in this process. Rats were subjected to either sh...

background: following pulmonary aspiration of gastric contents, a variety of conditions occurs ranging from the acute inflammatory response (aspiration pneumonitis) to an infectious process (aspiration pneumonia). they cause due to the failure of protecting mechanism of airway patency following poisoning toxicity. methods: patients with acute drug poisoning for assessment of aspiration-induced ...

The threat posed by the influenza A (H1N1) respiratory infections epidemic has triggered a worldwide response that has been felt in practically all aspects of respiratory medicine. The study of antiinflammatory treatments in lung injuries or of extracorporeal gas exchange techniques, tested during the epidemic, extends beyond the viral infection itself, with an impact upon the entire spectrum o...

Key points † Mechanical ventilation can have adverse effects on pulmonary function by several distinct mechanisms. † Patients undergoing one-lung ventilation or cardiopulmonary bypass are at increased risk of developing acute lung injury (ALI). † Protective ventilatory strategies may prevent or reduce ALI. † There is a lack of randomized controlled trials to guide optimal intra-operative ventil...

Reported herein are the cases of three infants who were born with serious intrathoracic injuries, apparently sustained at the time of the mother's involvement in a motor vehicle accident. The accidents occurred at 26th, 29th and 36th weeks of pregnancy and resulted in minimal injuries to the mothers themselves. The infants were born four weeks, three hours and two days later, respectively. Thei...

Thoracic traumas have an important place among all injuries as they can cause significant mortality and morbidity. The thoracic injuries are the large part of trauma with head and extremity injuries. Thoracic traumas are divided into two groups, including penetrating and blunt. The primary causes for penetrating traumas are wounds caused by gunshot and sharp objects. The lungs are the most inju...

Most knowledge has been accumulated on the mechanisms involved in the development of distant organ injuries during the course of severe acute pancreatitis. Among the various distant organ dysfunctions, both the development of acute lung injury and acute respiratory distress syndrome represent serious complications. In the following paragraphs the pathophysiological mechanisms capable of determi...

conclusions considering the fact that road-related accidents are quite predictable and controllable; therefore, the quality promotion of traumatic patients' care, and the road safety should be noted as problems associated with public health. objectives this study aimed to evaluate the patients with chest and abdominal trauma hospitalized in the surgery ward of poursina teaching hospital, g...