نتایج جستجو برای: lassa fever

تعداد نتایج: 96729  

Journal: :Journal of virology 2015
Angela L Rasmussen Nicolas Tchitchek David Safronetz Victoria S Carter Christopher M Williams Elaine Haddock Marcus J Korth Heinz Feldmann Michael G Katze

UNLABELLED To identify host factors associated with arenavirus virulence, we used a cynomolgus macaque model to evaluate the pathogenesis of Lujo virus (LUJV), a recently emerged arenavirus that caused an outbreak of severe viral hemorrhagic fever in southern Africa. In contrast to human cases, LUJV caused mild, nonlethal illness in macaques. We then compared this to contrasting clinical outcom...

2017
Lutz Ehlkes Maja George Gerhard Samosny Florian Burckhardt Manfred Vogt Stefan Bent Klaus Jahn Philipp Zanger

Due to rapid diagnosis and isolation of imported cases, community outbreaks of viral haemorrhagic fevers (VHF) are considered unlikely in industrialised countries. In March 2016, the first documented locally acquired case of Lassa fever (LF) outside Africa occurred, demonstrating the disease's potential as a cross-border health threat. We describe the management surrounding this case of LF in R...

Journal: :Antiviral research 2011
Juan C Zapata C David Pauza Mahmoud M Djavani Juan D Rodas Dmitry Moshkoff Joseph Bryant Eugene Ateh Cybele Garcia Igor S Lukashevich Maria S Salvato

Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. LCMV is considerably more benign for human beings than Lassa virus, however certain strains, like the LCMV-WE strain, can cause severe disease when the v...

Journal: :Emerging Infectious Diseases 2005

Journal: :Weekly releases (1997–2007) 2000

Journal: :Emerging Infectious Diseases 2010

2013
Toni Rieger Doron Merkler Stephan Günther

Lassa virus causes hemorrhagic Lassa fever in humans, while the related Old World arenaviruses Mopeia, Morogoro, and Mobala are supposedly apathogenic to humans and cause only inapparent infection in non-human primates. Here, we studied whether the virulence of Old World arenaviruses in humans and non-human primates is reflected in type I interferon receptor deficient (IFNAR(-/-)) mice by testi...

Journal: :The Journal of general virology 2007
Stefanie Müller Robert Geffers Stephan Günther

The pathogenesis of Lassa fever is poorly understood. As the liver is a major target organ of Lassa virus, gene expression in Lassa virus-infected HuH-7 cells, a differentiated human hepatoma cell line, was studied. Cellular mRNA levels were measured at the late phase of acute infection, when virtually all cells expressed large amounts of nucleoprotein, and virus RNA concentration had reached>1...

2012
Igor S. Lukashevich

Lassa virus (LASV) is the most prominent human pathogen of the Arenaviridae. The virus is transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing lethal Lassa Fever (LF). LASV has the highest human impact of any of the viral hemorrhagic fevers (with the exception of Dengue Fever) with an estimated several hundred thousand infections annually, resulting in tho...

2004
Michael B. A. Oldstone Stefan Kunz Jillian M. Rojek Mar Perez Christina F. Spiropoulou

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