Rituximab has greatly improved standard cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, but prospects remain poor in patients with adverse risk factors. We need to know whether the addition of rituximab also improves the efficacy of more intensive treatments and how to use molecular profiling to guide us in introducing other novel agents.

Introduction: Most B-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. Some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. Molecular techniques can be used as a helpful diagnostic tool in these cases. In this study, we assessed the value of polymerase chain reaction (PCR) t...

Primary cutaneous lymphomas, which are diagnosed with only skin involvement, can be of B or T cell origin. Due to their varied origin as well diverse presentations, these groups have been divided further into more descriptive and representative groups. The subtypes primary marginal zone lymphoma (PCMZL), follicle center (PCFCL), diffuse large lymphoma, leg type (PCDLBCL-LT) intravascular B-cell...

subcutaneous panniculitis-like t-cell lymphoma (sptcl) is an infrequent cytotoxic t-cell lymphoma of the skin with a unique immunophenotypic profile. here we describe this lymphoma in a 30-year-old iranian woman. she presented with periorbital edema, mandibular swelling with edematous areas on her face and two small lymph nodes (6-7mm) in the cervical area. histopathological findings revealed l...

primary cardiac lymphoma is a rare disease which mainly found in elderly men. it is usually a b-cell non-hodgkin’s lymphoma which primarily located in the heart and may involve the pericardium. the common presentations include massive pericardial effusion and heart failure. clinical diagnosis is often delayed in these patients and prognosis is dismal. we report a case of a 70-year-old man prese...