The ketogenic diet has been used in the treatment of intractable childhood epilepsy since the 1920s. A systematic review of the efficacy, adverse reactions, and costs associated with using the diet was performed. PubMed and Ovid searches were performed using the keywords epilepsy/therapy, dietary therapy, ketogenic diet, adverse events, and costs. Cochrane library was searched. Bibliographies o...

A ketogenic diet is a nonpharmacologic treatment strategy to control refractory epilepsy in children. Although this diet has been used successfully to reduce seizures since the 1920s, the anticonvulsant mechanism of ketosis remains unknown. The initiation of the diet requires an average four-day hospitalization to achieve ketosis in the patient as well as to provide thorough education on diet m...

Dietary manipulations are increasingly viewed as possible approaches to treating neurodegenerative diseases. Previous studies suggest that Alzheimer's disease (AD) patients present an energy imbalance with brain hypometabolism and mitochondrial deficits. Ketogenic diets (KDs), widely investigated in the treatment and prevention of seizures, have been suggested to bypass metabolic deficits prese...

The ketogenic diet is a valuable therapeutic approach for epilepsy, one in which most clinical experience has been with children. Although the mechanism by which the diet protects against seizures is unknown, there is evidence that it causes effects on intermediary metabolism that influence the dynamics of the major inhibitory and excitatory neurotransmitter systems in brain. The pattern of pro...

OBJECTIVE To evaluate the efficacy of the ketogenic diet in Indian children with uncontrolled epilepsy. STUDY DESIGN Prospective observational study. SETTING Hospital based. PATIENTS 105 children (age 4 months to 18 years) with uncontrolled epilepsy enrolled in the ketogenic diet program over a period of 9 years and followed up for 25.7+/- 20.3 months (median:17 months) on the ketogenic d...

The ketogenic diet as a treatment of persistent pyuria was first introduced by Clark and Helmholz in 19311. They found that when the acidity of the urine was increased below pH 5 4 the urine became bacteriafree in a short time and in conjunction with this the pus disappeared from the urine. Later Clark2 (1932) demonstrated that this sterilization was not due to the acidity of the urine. In 1933...

High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-pharmacological treatment for refractory epilepsy. A key mechanism of this treatment is thought to be the generation of ketones, which provide brain cells (neurons and astrocytes) with an energy source that is more efficient than glucose, resulting in beneficial downstream metabolic changes, such as increasing a...

Kanser, günümüz dünyasında en sık karşılaşılan bir sağlık sorunudur. hücre veya topluluğunun çeşitli çevresel genetik etmenlerle anormal şekilde çoğalması durumunda oluşan hastalıktır. Özellikle gelişen dünyada kanser sorunları gün geçtikçe artmaktadır. Önemli ve ciddi halk sağlığı sorunu olan kanserin tam kesin tedavisi yoktur. kemoterapi, radyoterapi, cerrahi operasyonlar gibi birçok tedavi y...