The aim of the present study is a comparative assessment echocardiographic characteristics in female and male mongrel rats. In experiments on anesthetized rats (ketamine 100 mg / kg, iv), it was shown that rats, size volume left ventricle are smaller than males, but compared with their ventricular ejection fraction, which characterizes its inotropic function, statistically significantly higher.

BACKGROUND Pain control in children is still a therapeutic dilemma. Preschool patients are affected from undesirable effects of postoperative pain more than adults. Tonsillectomy is associated with a high incidence of postoperative pain, not only complicating the recovery, but also delaying patients discharge. OBJECTIVES Despite employing different surgical and anesthetic strategies in post-t...

Background: The therapeutic potential of subanesthetic doses ketamine appears promising in unipolar depression; however, its effectiveness treating bipolar depression (BD) remains uncertain. Objective: This systematic review aimed to summarize findings on the use for treatment BD by assessing efficacy, safety, and tolerability. Design: Systematic review. Methods: We conducted a studies that inv...

Introduction: Preoperative anxiety is an issue of concern in paediatric anaesthesia practice. Forceful transfer children into the operating room can cause long-term psychological trauma. This clinical study compares intramuscular ketamine and a combination dexmedetomidine as anaesthetic premedicants terms +anxiolysis, sedation ease IV cannulation.
 Objectives: To compare level preoperative...

OBJECTIVE The N-methyl-D-Aspartate (NMDA) receptor has been proposed as a primary target for the treatment of neuropathic pain. The aim of the present study was to perform a meta-analysis evaluating the effects of (individual) NMDA receptor antagonists on neuropathic pain, and the response (sensitivity) of individual neuropathic pain disorders to NMDA receptor antagonist therapy. DESIGN PubMe...

Background: The aim of the study was to determine the efficacy and adverse effects of intravenous (iv) ketamine sedation administered by non-anesthetist physicians for painful procedures. Methods: A single-agent, procedural sedation protocol using titrated doses of ketamine iv (maximum 2 mg·kg 1 ) was conducted in outpatient pediatric oncology patients undergoing lumbar puncture (LP), bone marr...

Repurposing ketamine in the therapy of depression could well represent a breakthrough understanding etiology depression. Ketamine was originally used as an anesthetic drug and later its use extended to other therapeutic applications such analgesia treatment addiction. At same time, abuse recreational has generated concern for psychotropic potential long-term effects; nevertheless, fast acting a...

Studies designed to assess persistent postoperative pain (PPP) incidence after hepatectomies are lacking. Our aim was to assess PPP incidence 6 months after hepatectomies with intravenous (IV) or epidural (EPI) analgesia containing ketamine.Prospective observational comparative study between 2 cohorts of patients submitted to hepatectomy. Patients received 1 of 2 analgesic regimes containing ke...

In non-obese patients ketamine decreases inflammatory responses and prevents overexpression of immune responses. Its effect in obese patients is unknown. This prospective, blinded, randomized controlled trial was designed to determine the effect of ketamine on cytokines and immune cell responses after short-duration surgery in obese patients. Thirty-six patients received either ketamine 0.15 mg...