conclusions the addition of 50 mg of magnesium sulfate to a bupivacaine–fentanyl solution for intrathecal anesthesia improved the efficacy and duration of the analgesia without any significant side effects. the addition of 150 µg of neostigmine increased the incidence of hypotension, bradycardia, and nausea and vomiting. moreover, neostigmine failed to prolong analgesia duration. results group ...

Editor’s note: Please refer to the editorial by Cousins and Miller (pp. 1507–8) and the articles by Tucker et al. (pp. 1512–20 and 1521–7), Johansen et al. (pp. 1528–35), and Yaksh and Allen (pp. 1536–45) in this issue. I n the present issue of the journal, there are four papers focusing on intrathecal (IT) midazolam: a preclinical assessment of safety in sheep and pigs (1), a population evalua...

We studied the interaction of azole antimycotics with intravenous (IV) and oral midazolam using a cross-over design in 12 volunteers, who ingested placebo, itraconazole, or fluconazole for 6 days. A 7.5-mg dose of midazolam was ingested on the first day, 0.05 mg/kg was administered IV on the fourth day, and 7.5 mg orally on the sixth day. Itraconazole reduced the clearance of IV midazolam by 69...

objecive prolonged and uncontrolled refractory status epilepticus (se) is a life-threatening medical emergency in children (1,2,3). there is no consensus on the optimal therapy for refractory status epilepticus (1). the aim of this study was to develop a new method for treating patients with refractory status epilepticus. materials & methods ten children with refractory status epilepticus in mo...

The aim of this study was to investigate the effect of ketamine and midazolam on preventing the development of morphine tolerance and dependence and withdrawal syndrome in mice. In the present study different groups of mice were received morphine (50 mg/kg, s.c.), morphine (50 mg/kg, s.c.) + ketamine (25, 50, 75 mg/kg, i.p.) , morphine (50 mg/kg , s.c.) + midazolam (0.5, 1, 2 mg/kg, i.p.) , mor...

Midazolam is a benzodiazepine with rapid onset of action and short duration of effect. In healthy neonates the half-life (t 1/2) and the clearance (Cl) are 3.3-fold longer and 3.7-fold smaller, respectively, than in adults. The volume of distribution (Vd) is 1.1 L/kg both in neonates and adults. Midazolam is hydroxylated by CYP3A4 and CYP3A5; the activities of these enzymes surge in the liver i...

Background Self-extubation is a problem in pediatric intensive care unit (PICU) and can be harmful for children. Level of sedation is a determining factor for self-extubation. The aim of this study was to compare thr rate of self-extubation and duration of ventilation following different sedative modalities. Materials and Methods This prospective and randomized study was done in Mofid Children ...