We sought to quantitate infarct size using radioactive imaging techniques. Infarcts were created in closed chest dogs. Using a scintillation camera interfaced to a computer, infarct images were made in the anterior, left lateral, LAO, and RAO projections, 48 hours after infarction and 75 to 90 min following the intravenous injection of 15 mCi of Technetium 99m pyrophosphate (Tc-PYP). Images wer...

We previously developed a cross-sectional echocardiographic technique for quantitatively mapping the endocardial surface of the left ventricle and on which regions of abnormal wall motion can be superimposed in their correct spatial distribution. This endocardial mapping technique (EMT) provides a measure of the left ventricular endocardial surface area (ESA in cm2), the area of abnormal wall m...

Objective(s) Dracocephalum moldavica (D. moldavica) have been traditionally used as a cardiotonic agent in the folk medicine of some regions of Iran. In the present study, effects of total extract of D. moldavica on ischemia/reperfusion induced arrhythmias and infarct size investigated in isolated rat heart. Materials and Methods The isolated hearts were mounted on a Langendorff apparatus th...

MicroRNAs are non-coding RNAs. Studies have shown that miRNAs are expressed aberrantly in stroke. MiR-1 enhances ischemic damage, and previous study has demonstrated that reduction of miR-1 level has neuroprotective effect on Middle Cerebral Artery Occlusion(MCAO). Since apoptosis is one of the important process in neural protection, possible effect of miR-1 on this pathway has been tested in t...

Objective(s): Some histopathological alterations take place in the ischemic regions following brain ischemia. Recent studies have demonstrated some neuroprotective roles of crocin in different models of experimental cerebral ischemia. Here, we investigated the probable neuroprotective effects of crocin on the brain infarction and histopathological changes after transient model of focal cerebral...

Safranal is a monoterpene aldehyde found in saffron (Crocus sativus L.) petals. It has been previously reported that safranal has a wide range of activities such as antioxidant and anti-inflammatory effects. In this study, we examined the effect of safranal on brain injuries in a transient model of focal cerebral ischemia. Transient focal cerebral ischemia was induced by middle cerebral artery ...

the prevention of bbb breakdown and the subsequent vasogenic edema are important parts of the medical management of ischemic stroke. the purpose of this study was to investigate the ischemic tolerance effect of rosmarinus officinalis leaf hydro-alcoholic extract (rhe).five groups of animals were designed: sham (underwent surgery without mcao) and mcao groups, the mcao groups were pretreated ora...