Rome III diagnostic criteria separate patients with idiopathic chronic constipation into mutually exclusive categories of constipation-predominant irritable bowel syndrome (IBS-C) or functional constipation (FC). However, several experts think that these conditions are not different disorders, but parts of a continuum. To shed light on this issue, we examined studies that compared IBS-C with FC...

There are many recognised causes of constipation in the cat and the management of the condition depends on the clinician's ability to recognise the appropriate aetiology in each case. Most surgery therapies for constipation in the cat are related to the management of idiopathic megacolon, although causes such as pelvic outlet obstruction, complications of neutering surgery, perineal herniation,...

background: treatment of chronic constipation is creating one of the major problems for doctors and patients. pyridostigmine increases the gastrointestinal motility through the effects on cholinesterase. it seems that this mechanism can reduce chronic constipation. the aim of this study was to compare the effects of pyridostigmine and bisacodyl on chronic constipation. methods: this study was c...

BACKGROUND/AIM Behavioural therapy is effective in patients with chronic intractable constipation despite standard treatment, but long-term results in unselected patients are unclear. This study investigates the effects of behavioural therapy on symptoms, subjective well-being, and the physical and mental quality of life. METHODS Patients who had failed standard care for idiopathic chronic co...

I do not intend to give an account of the changing philosophies concerning the aetiology and treatment of the disease which followed upon Hirschsprung's (1888) first presentation of it as an entity in 1886. It required about 60 years of vague or wrong ideas to find the key to our present knowledge. That happened when our attention was diverted from the characteristic megacolon and was focused o...

Chronic idiopathic constipation (CC) and irritable bowel syndrome with predominant constipation (IBS-C) are the 2 most common conditions among functional gastrointestinal disorders. Despite current multiple therapeutic options, treatment remains challenging and dissatisfactory to many patients. Linaclotide is a novel therapeutic agent, which is a guanylate cyclase receptor agonist that stimulat...