This review is focused on the relationship between neuroendocrine regulation of GnRH/LH secretion and the expression of GnRH and GnRH receptor (GnRHR) genes in the hypothalamic-pituitary unit during different physiological states of animals and under stress. Moreover, the involvement of hypothalamic GABA-ergic, Beta-endorphinergic, CRH-ergic, noradrenergic, dopaminergic and GnRH-ergic systems i...

INDIAN PEDIATRICS 843 VOLUME 42AUGUST 17, 2005 We read with interest the brief report entitled “Assessment of adrenal endocrine function in Asian Thalassemics”(1). A large number of children in India undergo long term transfusions and are therefore at risk of hypothalamo-pituitary dysfunction. The paper makes an important observation of detecting biochemical evidence of adrenal hypofunction in ...

Sleep problems and circadian rhythms disturbances are common in many psychiatric disorders, with the most often-reported sleep problem in most cases being insomnia. In this paper, the main findings about sleep disturbances(features and therapy) and other biorhythm disturbances (biological timekeepers, CLOCK genes, GSK3, melatonin, hypothalamo-pituitary-adrenal axis, body temperature) are review...