BACKGROUND Following tissue injury, monocytes can enter the tissue and differentiate into fibroblast-like cells called fibrocytes, but little is known about what regulates this differentiation. Extracellular matrix contains high molecular weight hyaluronic acid (HMWHA; ∼2×10(6) Da). During injury, HMWHA breaks down to low molecular weight hyaluronic acid (LMWHA; ∼0.8-8×10(5) Da). METHODS AND ...

CONTEXT Intra-articular hyaluronic acid is a US Food and Drug Administration-approved treatment for knee osteoarthritis (OA); however, its efficacy is controversial. OBJECTIVE To evaluate whether intra-articular hyaluronic acid is efficacious in treating knee OA. DATA SOURCES We searched for human clinical trials in MEDLINE (1966 through February 2003) and the Cochrane Controlled Trials Reg...

PURPOSE To study the effect of acute or chronic intracameral injection of hyaluronic acid on intraocular pressure (IOP) in rats. METHODS Acute or chronic injections of hyaluronic acid were performed unilaterally in the rat eye's anterior chamber, whereas the contralateral eye was injected with saline solution. IOP was assessed daily or weekly by a tonometer in conscious rats. IOP was also ass...

AN attempt has been made to find the cells of origin and the time of origin during development of the vitreous hyaluronic acid. The adult vitreous body of those species so far examined seems to owe its characteristic jelly-like properties to the presence of small amounts of an insoluble collagen-like protein laid down in fibrous lamellae and a low concentration of hyaluronic acid. Earlier work ...

Injectable filling agents offer the promise of a better appearance without surgery and, among them, hyaluronic acid is the most commonly used. Although complications are rare, it is necessary to know the possible side effects and complications in order to be prepared for their management. That is why many researchers have been focusing on the interactions between hyaluronic acid and pathogens, ...

BACKGROUND Bioengineered hyaluronic acid derivatives are currently available that provide for safe and effective soft-tissue augmentation in the comprehensive approach to nonsurgical facial rejuvenation. Current hyaluronic acid fillers do not require preinjection skin testing and produce reproducible, longer-lasting, nonpermanent results compared with other fillers, such as collagen. METHODS ...

PURPOSE In the treatment of interstitial cystitis, intravesical hyaluronic acid application may be suggested as a treatment option. In this randomized prospective study, the authors aimed to identify whether instilling the hyaluronic acid with electromotive drug administration (EMDA) would increase the tissue uptake and improve the efficacy. MATERIALS AND METHODS The data of 31 patients who h...

ABS TRACT Introduction: Cutaneous fillings are a common procedure in today’s dermatology, with the majority being carried out with hyaluronic acid isolated or combined with other substances. Objective: To study the effects of adding hyaluronic acid and polyethylene glycol to cultures of human dermal fibroblasts. Methods: The study evaluated: cell proliferation and production of type 1 collagen ...

UNLABELLED The vibration of the vocal fold lamina propria is an important factor involved in vocal production and aging may change the amount of hyaluronic acid in the vocal fold leading to dysphonia. AIMS This study compares the concentration of hyaluronic acid in vocal folds of aged and young female rats. STUDY DESIGN experimental. MATERIALS AND METHODS We used the vocal cords of 13 fem...

It has been demonstrated in vitro that low concentrations of ascorbic acid rapidly depolymerize purified hyaluronic acid as judged from viscosity measurements (Skanse and Sundblad, 1943; Pigman, Rizvi, and Holley, 1961). Abrams and Sandson (1964) reported that the hyaluronic acid in rheumatoid synovial fluid is resistant to depolymerization by ascorbic acid in vitro. Serum proteins have been sh...