bovine oocytes matured in culture were denuded from cumulus cells with hyaluronidase and by repeat pipetting trough a fine pasture pipete and were inseminated with frozen-thawed spermatozoa in a protein-free bo medium containing 5m m-caffeine, l0 mg heparin/ml and with or without polyvinyl pyrrolidone (pvp) and different concentrations of hyaluronic acid. when oocytes were inseminated in the ab...

background: analysis of human cancer serum has revealed the presence of high amounts of hyaluronan (hyaluronic acid, ha) when compared to human normal serum, it is well documented that ha and its receptors, known as hyaladherins (habps) are involved in matrix regulation, cell proliferation, migration and malignant tumour progression. these hyaladherins not only interact with hyaluronan at the m...

conclusions use of ha in an algorithm model, is an extra and valuable tool for assessing liver necro inflammatory injuries- in parallel with liver biopsy- but more comprehensive studies are needed to approve the use of ha as an appropriate clinical tool. results there are several scientific studies indicating ha as a biomarker for high score fibrosis and cirrhosis in various liver diseases alon...

conclusions the most effective enhancer for aha and ha were liquid paraffin and glycerol, respectively. the most effective surfactant for both aha and ha was tween 80. the effects of the enhancers were increased by prolonging the exposure time. results after 1.5 and 12 hours, the maximum permeated amount of aha were 89.8 and 342.5 mg, respectively, which related to the formulations with liquid ...

background: vaginal atrophy is a common complication in menopause which does not improve with time and, if untreated, can affect the quality of life for women. the aim of this study was to compare the effectiveness of the vaginal cream of hyaluronic acid and conjugated estrogen (premarin) in treatment of vaginal atrophy. methods: this study was a randomized controlled clinical trial on 56 menop...

injection of synthetic fillers for soft tissue augmentation is increasing over the last decade. one of the most common materials used is hyaluronic acid (ha) that is safe and temporary filler for soft tissue augmentation. we present a case of 54-year-old female who experienced vascular occlusion and nasal alar necrosis following ha injection to the nasolabial folds. she suffered from pain, necr...

background the platelet-rich plasma (prp) and hyaluronic acid (ha) constitute a system of tissue growth that can regenerate damaged tissue. this study was performed to evaluate the effect of prp and ha in treatment of complications of achilles tendon reconstruction. methods we selected ten patients affected by achilles tendon injuries resulting from post-surgical complications subsequent to ten...