introduction drug-induced liver injury is a frequent cause of hepatic dysfunction. several drugs have been identified to cause autoimmune hepatitis (aih). environmental chemicals are capable of triggering a certain degree of liver injury. however, toxin induced aih is rare. conclusions chronic (long-term) exposures to dichlorvos can lead to aih. a detailed inquiry of medical history and liver b...

advancements in medical science have led to the development of complex surgeries that improve survival in patients with liver disease. assessments of the indications and contraindications for surgery and risk factors are the most important steps prior to any surgery in this population. particular attention is essential to assess for the presence of pre-surgical ascites, hepatic encephalopathy a...

background: paraquat (pq) poisoning is highly fatal; and therefore, clinicians should be familiar with prompt approach to and poor prognostic features of this type of poisoning. hence, in this study, clinical profile, management and outcome of a series of patients with pq poisoning are presented. methods: a retrospective review of medical records of patients poisoned with pq who were treated at...

OBJECTIVES The anti-tumour agent S-1 comprises tegafur (a prodrug of 5-fluorouracil; 5-FU), gimeracil (2-chloro-2,4-dihydroxypyridine (CDHP); a competitive inhibitor of 5-FU metabolism) and oteracil potassium. The effect of hepatic dysfunction induced by dimethylnitrosamine (DMN) on the pharmacokinetics of 5-FU after administration of S-1 to rats was investigated. METHODS S-1 (5 mg/kg) was ad...

Introduction: Abnormal liver function tests (LFts) are a common reason for referral to hospital although in some cases, no obvious hepatic pathology is found. Yet, they can indicate other disease processes not immediately obvious. A rare cause of cholestatic hepatic dysfunction is the paraneoplastic manifestation of malignancy. case report: Herein, we report a case referred with anicteric chole...

BACKGROUND Hepatic hemangioma is a congenital tumor of the mesenchymal tissues of the liver. While typically benign, these tumors can occasionally grow to sufficient size to cause a number of symptoms, including pain, severe hepatic dysfunction, or, rarely, consumptive coagulopathy. In such instances, surgical treatment may be warranted. CASE REPORT We present a case of a symptomatic giant he...