3-Formyl-4-hydroxyphenylguanidine hydrochloride and its Schiff base copper(II), zinc(II), and iron(III) chelates were synthesized and their inhibitory activity against bovine beta-trypsin were determined. Syntheses of Schiff base metal chelates were carried out from 3-formyl-4-hydroxyphenylguanidine, various L-amino acids, and divalent metal acetate. Their structures were established on the bas...

The catalytic activity of several proteolytic enzymes is altered by high concentrations of urea and guanidine salts (2-4). These studies, in conjunction with certain physical data, indicate that hydrogen bonding in the secondary structure of these enzymes is essential for maintenance of their catalytic function. Because of the increasing amount of information that is available concerning the st...

qppg. 1961. -The permeability of the squid axon membrane to choline, guanidine, thiourea, urea, sucrose, starch, and cesium was investigated by use of radiotracers. In the resting state, the time constant for the loss of intracellular radioactive (free) choline, guanidine, and cesium was of the same order of magnitude as that for labeled sodium or potassium ions. Choline ion was found to bind r...

In this study molecular topology based QSAR has been applied to predict the reaction yield and anticancer activity of 18 imidazole and guanidine derivatives. Four properties were evaluated, namely reaction yield, anti prostatic-cancer activity, anti breast-cancer activity and anti lung-cancer activity. The four models have been validated by both internal and cross validation, and also by random...

The guanidine-II (mini-ykkC) riboswitch is the smallest of the guanidine-responsive riboswitches, comprising two stem loops of similar sequence. We have solved high-resolution crystal structures of both stem loops for the riboswitch from Gloeobacter violaceus. The stem loops have a strong propensity to dimerize by intimate loop-loop interaction. The dimerization creates specific binding pockets...

Guanidine derivatives are suspected of contributing to the toxic manifestations of uremia. We describe a method for measurement of guanidine derivatives in 5-ml samples of plasma by liquid chromatography. Concentrations of guanidinosuccinate and guanidinobutyrate in plasma were significantly increased both in undialyzed patients with chronic renal failure (5.54 +/- 0.94 and 17.5 +/- 4.07 mg/lit...

A new preparative procedure for bovine milk xanthine oxidase avoids exposure of the enzyme to proteases. The enzyme so obtained exhibited a molecular weight of about 300,000 as did chicken liver xanthine dehydrogenase. The former readily yielded species with a molecular weight of 150,000 in guanidine and in acid but could not be resolved into smaller subunits. Aldehyde oxidase of rabbit liver e...

The synthesis of indolo[2,3-b]quinoline derivatives containing guanidine, amino acid or guanylamino acid substituents as well as their in vitro evaluation for the cytotoxic and antifungal activity are reported. The influence of the guanidine group on the selective cytotoxic and hemolytic properties of indolo[2,3-b]quinoline was investigated. Most of the compounds displayed a high cytotoxic acti...

In the title asymmetric di-cyclo-hexyl-phenyl-guanidine, C25H41N3, the central guanidine C atom deviates by only 0.004 (2) Å from the central plane defined by the three N atoms. The benzene and the cyclo-hexyl rings are rotated out of the central plane of the N3C unit by 85.63 (12)° (benzene) and 51.52 (9) and 49.37 (12)° (cyclohexyl). The crystal packing features only by van der Waals inter-ac...