Sex differences in adrenal cortex structure and function are well known in different species. In the rat, they are manifested as larger adrenal cortex and higher corticosterone secretion by females compared with males. These sex differences depend, among others, on functioning of the hypothalamic-pituitary-adrenal axis (HPA). In this aspect, it is widely accepted that testosterone exerts an inh...

We have reported that mid-region fragments of human parathyroid hormone (hPTH), exemplified by hPTH-(28-48), stimulated [3H]thymidine incorporation into DNA and increased the specific activity of the brain-type isoenzyme of creatine kinase (CK) in both skeletal-derived cell cultures (ROS 17/2.8 cells) and immature rat epiphyseal cartilage and diaphyseal bone, without stimulating cyclic AMP synt...

In a study of the role of sex and iodine deficiency in the growth and function of thyroid carcinoma in rats, half of the male and female litter rats were surgically gonadectomized at the age of two months. One month later, all animals were implanted with a transplantable, autonomous, follicular thy roid carcinoma and one-half of all animals were given an iodine-deficient diet. Six weeks later, ...

In a study of the role of sex and iodine deficiency in the growth and function of thyroid carcinoma in rats, half of the male and female litter rats were surgically gonadectomized at the age of two months. One month later, all animals were implanted with a transplantable, autonomous, follicular thy roid carcinoma and one-half of all animals were given an iodine-deficient diet. Six weeks later, ...

Peripheral administration of alcohol has been demonstrated to cause significant increases in neurosteroid levels in the brain and periphery. These findings have led to several theories suggesting a role for neurosteroids in the actions of alcohol. However, the anatomical sources of these steroids (e.g., brain or periphery) are as yet unknown. This study utilized gas chromatography/mass spectrom...