Partially purified hemoglobin A2 has been examined for the existence of glycosylated components by isoelectric focusing and by acid agar gel electrophoresis. Bands analogous to the glycohemoglobin derivatives of hemoglobin A, hemoglobin-A1.a.b.c, were readily detected. Evidence that these minor bands are in fact glycohemoglobins was obtained by showing that 14C-glucose bound to hemoglobin A2 mo...

To address the question, Do laboratory tests cost money or save money? we have used as a model for discussion a common chronic disease, diabetes mellitus, and a widely used laboratory test, that for glycohemoglobin, a measure of long-term glycemia used to manage diabetic patients. Diabetes mellitus is serious, highly prevalent, and costly. In 1992, $1 of every $7 spent on health in the US was f...

Introduction: Diabetes mellitus has long been recognized as a major cause of mortality and morbidity. The true frequency of the disorder is difficult to estimate because of differing diagnostic criteria but it is clearly the most common of the serious metabolic disorders occurring in roughly I to 4 percent of the U.S. population. It is a leading cause of mortality in this country, taking over 3...

Drs. Riddle and Gerstein (1) suggest renaming the hemoglobin glycation index (HGI) to reflect the possibility that interindividual variation in HGI in the ACCORD trial could be an artifact of how blood glucose was measured. HGI is the difference between an individual’s observed HbA1c and a predicted HbA1c derived by inserting a time-matched blood glucose measurement into a regression equation d...

Recently, we observed falsely low results by the Abbott IMx Glycated Hemoglobin assay apparently caused by a high number of leukocytes in patients with chronic lymphocytic leukemia. Because chronic lymphocytic leukemia and diabetes mellitus (monitored by glycohemoglobin measurements) occur more frequently in the elderly, we examined this interference further. The IMx Glycated Hemoglobin assay (...

The high precision of the results may enable single measurements instead of multiple determination, thereby reducing costs. The significantly lower values for ghrelin in citrate plasma may only partially (ϳ12%) be explained by dilution with the anticoagulating liquid in the tubes (118 Ϯ 15 ␮L). The discrepancy between citrate plasma and serum was ϳ25%, a discrepancy that is too high for a recom...

BACKGROUND We assessed and directly compared weight loss effects of sibutramine and orlistat treatment in a group of obese, poorly-controlled type 2 diabetic patients. METHODS This study recruited 34 diabetic subjects [glycohemoglobin (HbA1c) > 8%] with a body mass index of at least 27 kg/m2. A 36-week, three-phase, prospective, randomized, cross-over comparative study was conducted. In phase...