Glucose modulates beta cell insulin secretion via effects on ATP-sensitive potassium (KATP) channels. To test the hypothesis that glucose exerts a similar effect on neuronal function, local glucose availability was varied in awake rats using microdialysis in the substantia nigra, the brain region with the highest density of KATP channels. 10 mM glucose perfusion increased GABA release by 111 +/...

Improving the solubility and changing the dissolution rate of the poorly soluble active pharmaceutical ingredients (API’s) AMG 517, glipizide, and naproxen through the preparation of eutectic mixtures was investigated. Mixtures of the API’s with other small molecules were prepared to construct a phase diagram used to identify the eutectic mixture compositions. The search for a eutectic mixture ...

Objective: To study the long term cardiovascular effects of oral antidiabetic agents in non-diabetic patients with insulin resistance. Patients: 181 African American subjects with insulin resistance and normal glucose tolerance test were randomised to receive glipizide 5 mg/day (n = 25), metformin 500 mg/day (n = 59), or placebo (n = 97) for 24 months. Insulin sensitivity, glucose tolerance, li...

The pancreatic B-cell GLUT2 transporter and glucose metabolism were examined in isolated rat islets subjected to treatments affecting insulin secretion. Diazoxide was used to inhibit, while glipizide or depolarization of the plasma membrane with a high extracellular K(+) concentration were used to stimulate insulin release in short-term experiments. Islet GLUT2 and insulin were determined by qu...

The objective of research was to explore the suitability of lipids like compritol 888 ATO and stearic acid as release retardant to develop sustained release (SR) tablets. The SR micromatrices of lipid (s) and glipizide were prepared (LM1- LM6) as intermediate product by fusion method and assessed for various pharmacotechnical properties. Micromatrices were formulated as SR tablets (F1-F6) by di...

Background: Type 2 diabetes mellitus (DM), a common metabolic disorder, prevalence of which is predicted to rise in virtually every country with the greatest increase expected in developing countries. Modification in diet and life style are usually insufficient to provide good, long-term metabolic control of type 2 DM; pharmacological adjuvants are required in majority of patients. As there is ...

In the present work glipizide based microemulsion was developed and its usefulness as topical drug carrier system for the non-insulin dependent diabetes mellitus (NIDDM) was investigated. Microemulsion was prepared by water titration method using oleic acid as oil phase, tween-80 as surfactant and propylene glycol as co-surfactant. Menthol as a permeation enhancer was added to a final drug-load...

Glipizide is an effective antidiabetic agent, however, it suffers from relatively short biological half-life. To solve this encumbrance, it is a prospective candidate for fabricating glipizide extended release microcapsules. Microencapsulation of glipizde with a coat of alginate alone or in combination with chitosan or carbomer 934P was prepared employing ionotropic gelation process. The prepar...