We previously found that the protein subunits of GPI-transamidase complex (e.g. PIG-U, PIG-T and GPAA1) play critical roles of oncogenes in human bladder and breast cancers manifesting their activities through signaling mechanisms that involve urokinase receptor/Stat3 and paxillin pathways. We report here that cigarette smoke extract (CSE) enhanced colony formation and invasiveness of certain h...

Azadirachta indica and Curcuma longa is the most useful traditional plant being used in India for medicinal purposes from centuries. There is evidence that these plants have anti-inflammatory, analgesic, antipyretic, antioxidant and anticancer activities. Work has been done on the wound-healing and anti-inflammatory activities of these plants and investigation is needed to understand the mechan...

To understand molecular genetic characteristics of Korean pigs, the genetic relationships of nine pig breeds including two Korean pigs (Korean native pig and Korean wild pig), three Chinese pigs (Min pig, Xiang pig, and Wuzhishan pig), and four European breeds (Berkshire, Duroc, Landrace, and Yorkshire) were characterized from a 16-microsatellite loci analysis. The mean heterozygosity within br...

several therapeutic effects including hypnotic, antispasmodic, treatment of abdominal and chest pain and strengthening the heart have been described for the flowers of rosa damascena. north american indian tribes use a decoction of the roots obtained from the rosa damascena plant as a cough remedy and to treat eye problem. therefore, in the present study the antitussive effect of this plant in ...

Department of Psychology, University of Pennsylvania, Philadelphia, PA, U.S.A. Department of Biology, University of Pennsylvania, Philadelphia, PA, U.S.A. Department of Psychology, University of Michigan, Ann Arbor, MI, U.S.A. Department of Ecology & Evolutionary Biology, University of Michigan, Ann Arbor, MI, U.S.A. Cognitive Ethology Laboratory, German Primate Center, University of Gottingen,...

Inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. So the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and ipratropium against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pig. ...

The IGF-1 gene has been implicated as a candidate gene for the regulation of pig growth traits. We analyzed exons 3 and 4 of IGF-1 gene polymorphisms of the Banna mini-pig (28), the Tibetan mini-pig (30), the Junmu pig (55), and L. Yorkshire species (50) using PCR-SSCP. Three genotypes in exon 3 and 6 genotypes in exon 4 were observed, among which, one single nucleotide polymorphism, G201A, on ...

This paper considers current medical and legal perspectives on patients' right to assistance in dying. In highlighting the competing policy objectives that must be resolved, it examines failed legislative initiatives in Washington and California. It also considers a pending New Hampshire proposal. The last shows the difficulty of simultaneously alleviating physician's objections and achieving p...

Although empirical research has investigated what we ideally seek in a romantic partner for decades, the crucial question of whether ideal partner preferences actually guide our mating decisions in real life has remained largely unanswered. One reason for this is the lack of designs that assess individuals' ideal partner preferences before entering a relationship and then follow up on them over...

A first survey of the Southampton and South West Hampshire Health Authority showed an overall prevalence of multiple sclerosis of 99/100,000 in a population of 417,000 on 1 January 1987. This finding is similar to other recent first surveys in the South of the United Kingdom and only repeat surveys will show if case only repeat surveys will show if case ascertainment has been more complete in t...