نتایج جستجو برای: genomic scan

تعداد نتایج: 195881  

2014
Kunzhe Dong Na Yao Yabin Pu Xiaohong He Qianjun Zhao Yizhao Luan Weijun Guan Shaoqi Rao Yuehui Ma Marinus FW. te Pas

High altitude environments are of particular interest in the studies of local adaptation as well as their implications in physiology and clinical medicine in human. Some Chinese pig breeds, such as Tibetan pig (TBP) that is well adapted to the high altitude and Dahe pig (DHP) that dwells at the moderate altitude, provide ideal materials to study local adaptation to altitudes. Yet, it is still s...

Journal: :The Journal of clinical investigation 1998
R E Pratley D B Thompson M Prochazka L Baier D Mott E Ravussin H Sakul M G Ehm D K Burns T Foroud W T Garvey R L Hanson W C Knowler P H Bennett C Bogardus

Type 2 diabetes mellitus is a common chronic disease that is thought to have a substantial genetic basis. Identification of the genes responsible has been hampered by the complex nature of the syndrome. Abnormalities in insulin secretion and insulin action predict the development of type 2 diabetes and are, themselves, highly heritable traits. Since fewer genes may contribute to these precursor...

Journal: :Journal of applied physiology 2000
C Bouchard T Rankinen Y C Chagnon T Rice L Pérusse J Gagnon I Borecki P An A S Leon J S Skinner J H Wilmore M Province D C Rao

This study aimed to identify human genomic regions that are linked to maximal oxygen uptake (VO(2 max)) in sedentary individuals or to the responsiveness of VO(2 max) to a standardized endurance training program. The results of a genomic scan based on 289 polymorphic markers covering all 22 pairs of autosomes performed on the Caucasian families of the HERITAGE Family Study are presented. The me...

2015
Alice Kujur Deepak Bajaj Hari D. Upadhyaya Shouvik Das Rajeev Ranjan Tanima Shree Maneesha S. Saxena Saurabh Badoni Vinod Kumar Shailesh Tripathi C.L.L. Gowda Shivali Sharma Sube Singh Akhilesh K. Tyagi Swarup K. Parida

We identified 44844 high-quality SNPs by sequencing 92 diverse chickpea accessions belonging to a seed and pod trait-specific association panel using reference genome- and de novo-based GBS (genotyping-by-sequencing) assays. A GWAS (genome-wide association study) in an association panel of 211, including the 92 sequenced accessions, identified 22 major genomic loci showing significant associati...

Journal: :Journal of applied physiology 2001
Y C Chagnon T Rice L Pérusse I B Borecki M A Ho-Kim M Lacaille C Paré L Bouchard J Gagnon A S Leon J S Skinner J H Wilmore D C Rao C Bouchard

An autosomal genomewide search for genes related to body composition and its changes after a 20-wk endurance-exercise training program has been completed in the HERITAGE Family Study. Phenotypes included body mass index (BMI), sum of eight skinfold thicknesses, fat mass (FM), fat-free mass, percent body fat (%Fat), and plasma leptin levels. A maximum of 364 sib-pairs from 99 Caucasian families ...

2015
Wei Zhang Eric R. Gamazon Xu Zhang Anuar Konkashbaev Cong Liu Keely L. Szilágyi M. Eileen Dolan Nancy J. Cox

Functional annotation of genetic variants including single nucleotide polymorphisms (SNPs) and copy number variations (CNV) promises to greatly improve our understanding of human complex traits. Previous transcriptomic studies involving individuals from different global populations have investigated the genetic architecture of gene expression variation by mapping expression quantitative trait l...

The development of genomic selection has created new strategies in animal breeding programs. The aim of this study was to investigate the efficiency of genomic selection in breeding programs of native hens. In this study, a reference scenario with 3380 birds using pedigree and phenotypic information was simulated and the expected genetic progress was derived deterministically with the software ...

Journal: :Biostatistics 2011
Mark R Segal Yuanyuan Xiao Fred W Huffer

Methods for formally evaluating the clustering of events in space or time, notably the scan statistic, have been richly developed and widely applied. In order to utilize the scan statistic and related approaches, it is necessary to know the extent of the spatial or temporal domains wherein the events arise. Implicit in their usage is that these domains have no "holes"-hereafter "exclusion zones...

Journal: :Tsinghua Science and Technology 2007

2012
Alfred Amambua-Ngwa Kevin K. A. Tetteh Magnus Manske Natalia Gomez-Escobar Lindsay B. Stewart M. Elizabeth Deerhake Ian H. Cheeseman Christopher I. Newbold Anthony A. Holder Ellen Knuepfer Omar Janha Muminatou Jallow Susana Campino Bronwyn MacInnis Dominic P. Kwiatkowski David J. Conway

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiable signatures of balancing selection. To comprehensively survey for genes under such selection in the human malaria parasite Plasmodium falciparum, we generated paired-end short-read sequences of parasites in clinical isolates from an endemic Gambian population, which were mapped to the 3D7 strai...

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