This study was aimed to investigate the association of restriction fragment length polymorphisms (RFLPs) for pepsinogen genes with peptic ulcer disease. Eighty unrelated controls, 61 patients with gastric ulcer, and 57 patients with duodenal ulcer were studied. No genetic polymorphisms for pepsinogen A were detected by EcoRI digestion in Japanese subjects but a 100 base pairs insertion-deletion...

we have studied the ulcerogenic effect of indomethacin in stretozocin. induced diabetic rats. streptozocin (65 mg kg-1) was injected intraperitoneally to male wistar rats. the blood glucose concentration was determined continuously. blood glucose level increased significantly (p<0.001) after 30 days. gastric erosions were induced by intraperitoneal injection of indomethacin (50 mg kg-1) in fast...

strongyloides stercoralis is a free living tropical and semitropical soil nematode which its larva penetrates skin. it can complete its life cycle in human body and causes autoinfection. most patients have no frank symptoms. but respiratory, gastrointestinal and skin manifestation may occur. we report a 76 year old man admitted to emergency room with muscle weakness, dyspnea, nausea, vomiting w...

OBJECTIVE Gut-brain axis (GBA) is very important in creation and modulation of gastrointestinal problems. Aloe vera gel has gastroprotective properties. The purpose of this study was to evaluate the effect of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid gastric ulcer induction. MATERIALS AND METHODS Gastric ulce...

SAITO, A. Relation of the Acidity of Gastric Juice to Cancer and Ulcer of the Gastroduodenal Tract. Tohoku J. exp. Med., 1973, 111 (4), 323-345-The author has statistically studied the acidity of gastric juice obtained from 1,100 cases of gastric cancer, 29 cases of gastric polyps, one case of gastric sarcoma, one case of gastric myoma, 5 cases of duodenal cancer, 570 cases of gastric ulcer, 90...

This study was performed to determine the anti-ulcer effects of ethanol extract of Parkia speciosa on Indomethacin induced peptic ulcer in Albino rats. Rats of female sex weighing between 150 g 200 g were used. Rats were divided into six groups with six rats in each group. Omeprazole (20 mg/kg) were used as a standard drug for this study. Parkia speciosa extract were given in three different do...

Alcohol consumption has been commonly associated with gastric mucosal lesions including gastric ulcer. Diosmin (DIO) is a natural citrus flavone with remarkable antioxidant and anti-inflammatory features that underlay its protection against cardiac, hepatic and renal injuries. However, its impact on gastric ulcer has not yet been elucidated. Thus, the current study aimed to investigate the pote...

Circadian rhythms are driven by endogenous clock gene and affects in several gastric parameters causing ulcerogenesis. The study was aimed to evaluate the time dependent antiulcer activity of hydroxyzine in cold-stress-induced ulcer model. The ulcer protection effect of hydroxyzine was studied at various time intervals (9 am, 1 pm, 5 pm, 91 pm, 1 am and 5 am) in cold stress ulcer model using wi...

BACKGROUND Serum response factor (SRF) is crucial for gastric ulcer healing process. The study determined if gastric ulcer tissues up-regulate SRF and if such up-regulation correlated with co-morbidities and the risk of recurrent bleeding. METHODS Ulcer and non-ulcer tissues were obtained from 142 patients with active gastric ulcers for SRF expression assessed by immunohistochemistry. Based o...

BACKGROUND Capsaicin protects the gastric mucosa against experimental injury while capsaicin desensitisation reduces the rate of gastric ulcer healing. The effect of exogenous capsaicin on gastric ulcer healing has not to date been reported. AIM/METHOD To investigate the effect of capsaicin, cimetidine, and in combination, given intragastrically in the healing of acetic acid induced chronic g...