The present study was undertaken to evaluate the anti-depressive activity of a polyherbal formulation (PF) after 28 days administration by using a rat forced swimming test (FST) and tail suspension test (TST). Animals were divided into six groups (n=6/group): group-1: The control rats received injections of 0.5% CMC solution only; group 2: FST+vehicle, groups 3: FST+SER (10 mg/kg, i.p.); group ...

Antidepressant drugs modify in different ways the activity of neurons, by increasing monoamines levels and by modulating ion channels. Sodium channels are molecular targets for antiepileptic drugs, which can also be mood stabilizers (i.e. lamotrigine, topiramate, phenytoin, carbamazepine, valproic acid). After a short overview on the sodium channels and the interaction with antidepressants and ...

Objective: The purpose of this study was to determine the activity and optimal dose Muntingia calabura L. ethanol extract as an antidepressant using Forced Swimming Test (FST), Tail Suspensions (TST), Open Field (OFT).
 Methods: Twenty-five male Swiss-Webster mice were randomly divided into five groups. Group 1 a control group, got vehicle (1% w/v CMC). As positive control, group 2 0.052 m...

Objective(s):Chronic stress has been linked to the pathophysiology of mood disorders including anxiety and depression. In this study, we aimed to investigate the effect of troxerutin (TRX), as a flavonol, on stress-induced anxiety and depression.Materials and Methods: 56 animals were randomly divided into seven groups (n=8 per group) as follows: control, saline, TRX 50, TRX 150, TRX 300, Diazep...

objective(s): this study evaluated the effect of swimming exercise during spontaneous methamphetamine (meth) withdrawal on the anxiety, depression, obsessive-compulsive disorder (ocd) and voluntary meth consumption in meth-dependent rats.  materials and methods: male wistar rats were repeatedly administered with bi-daily doses of meth (2 mg/kg, subcutaneous) over a period of 14 days. exercised ...

The forced swim test (FST), originally developed by Porsolt et al., is highly valuable for assessing the antidepressant-like effects of the majority of currently-available antidepressants. Lucki et al. modified some parameters of the traditional FST in order to facilitate the differentiation between serotonergic and noradrenergic classes of antidepressant drugs. In addition, the FST is one of t...

Duloxetine is a selective serotonin and noradrenaline reuptake inhibitor used as antidepressant. However, its mechanisms of action are not fully understood. This study investigated the effect of duloxetine in the mouse forced swimming test (FST) and in the tail suspension test (TST) and the involvement of the NMDA receptors and the l-arginine-NO-cGMP pathway in its effect in the FST. Duloxetine...

Antagonism of the kappa opioid receptor (KOR) has been reported to have anti-depressant-like properties. The dynorphin/KOR system is a crucial neurochemical substrate underlying the pathologies of addictive diseases, affective disorders and other disease states. However, the molecular underpinnings and neuroanatomical localization of the dysregulation of this system have not yet been fully eluc...

Oleamide, a fatty acid amide accumulates selectively in the cerebrospinal fluid of sleep deprived cats and rats. Oleamide has been reported to have effects on a wide range of receptors and neurotransmitter systems especially the centrally acting ones for example, dopamine acetylcholine, serotonin, gamma aminobutyric acid (GABA), cannabinoid and vanilloid among others. This suggests a wide range...

PURPOSE Chronic stress is a risk factor for behavioral deficits, including impaired memory processing and depression. Exercise is well known to have beneficial impacts on brain health. METHODS Mice were forced to treadmill running (4-week) during chronic restraint stress (6h/21d), and then behavioral tests were conducted by Novel object recognition, forced swimming test: FST, sociality test: ...