نتایج جستجو برای: fimh hlya

تعداد نتایج: 764  

Journal: :Indian journal of experimental biology 2009
H H Musa S F He S L Wu C H Zhu Z H Liu Z N Zhang V S Raj R X Gu G Q Zhu

Adhesion of pathogen to host cells is an important prerequisite for successful colonization and establishment of the pathogenesis. The aim of this study is to examine the function of FimH adhesin in the adherence of avian pathogenic E. coli to porcine intestinal epithelial cell lines (IPEC-J2) and human lung epithelial cell line (A549) in an in vitro infection model. Three strains of avian path...

2017
M. Srivani Y. Narasimha Reddy K. V. Subramanyam M. Ramakoti Reddy T. Srinivasa Rao

AIM Aim of the study was to investigate the prevalence, virulence gene profiles, and antimicrobial resistance pattern of Shiga toxigenic Escherichia coli (STEC) in diarrheic buffalo calves from Andhra Pradesh and Telangana States. MATERIALS AND METHODS A total of 375 fecal samples from diarrheic buffalo calves of 1-7, 8-30, 31-60, and 61-90 days age were collected from which STEC were isolate...

2017
Alaullah Sheikh Rasheduzzaman Rashu Yasmin Ara Begum F Matthew Kuhlman Matthew A Ciorba Scott J Hultgren Firdausi Qadri James M Fleckenstein

Enterotoxigenic Escherichia coli (ETEC), defined by their elaboration of heat-labile (LT) and/or heat-stable (ST) enterotoxins, are a common cause of diarrheal illness in developing countries. Efficient delivery of these toxins requires ETEC to engage target host enterocytes. This engagement is accomplished using a variety of pathovar-specific and conserved E. coli adhesin molecules as well as ...

Journal: :Infection and immunity 2003
Florence Hommais Stéphanie Gouriou Christine Amorin Hung Bui Mohamed Chérif Rahimy Bertrand Picard Erick Denamur

Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and "commensal-adaptive" (A202V) mutations were evidenced in B2 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occu...

2010
Thisbe K Lindhorst Kathrin Bruegge Andreas Fuchs Oliver Sperling

FimH is a mannose-specific bacterial lectin found on type 1 fimbriae with a monovalent carbohydrate recognition domain (CRD) that is known from X-ray studies. However, binding studies with multivalent ligands have suggested an additional carbohydrate-binding site on this protein. In order to prove this hypothesis, a bivalent glycopeptide ligand with the capacity to bridge two putative carbohydr...

Journal: :Infection and immunity 2011
Veronika Tchesnokova Pavel Aprikian Dagmara Kisiela Sarah Gowey Natalia Korotkova Wendy Thomas Evgeni Sokurenko

Escherichia coli causes about 90% of urinary tract infections (UTI), and more than 95% of all UTI-causing E. coli express type 1 fimbriae. The fimbrial tip-positioned adhesive protein FimH utilizes a shear force-enhanced, so-called catch-bond mechanism of interaction with its receptor, mannose, where the lectin domain of FimH shifts from a low- to a high-affinity conformation upon separation fr...

Avian pathogenic Escherichia coli (APEC) are responsible for wide ranges of extra-intestinal diseases in poultry including colibacillosis, cellulitis, coligranuloma and yolk sac infection. Numbers of virulence are considered important in the pathogenicity of these diseases. The aims of the present study were phylogenetic typing and virulence genes detection in Escherichia coli </em...

Journal: :Molecules 2017
Mohamed Touaibia Eva-Maria Krammer Tze C Shiao Nao Yamakawa Qingan Wang Anja Glinschert Alex Papadopoulos Leila Mousavifar Emmanuel Maes Stefan Oscarson Gerard Vergoten Marc F Lensink René Roy Julie Bouckaert

Antagonists of the Escherichia coli type-1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against acute and recurrent bacterial infections. In this study α-d-mannopyranosides O- or C-linked with an alkyl, alkene, alkyne, thioalkyl, amide, or sulfonamide were investigated to fit a hydrophobic substituent with up to two aryl groups within ...

Journal: :The Journal of biological chemistry 2002
Indira U Mysorekar Matthew A Mulvey Scott J Hultgren Jeffrey I Gordon

Uropathogenic Escherichia coli (UPEC), the principal cause of urinary tract infection in women, attaches to the superficial facet cell layer of the bladder epithelium (urothelium) via its FimH adhesin. Attachment triggers exfoliation of bacteria-laden superficial facet cells, followed by rapid reconstitution of the urothelium through differentiation of underlying basal and intermediate cells. W...

Journal: :Journal of bacteriology 2007
Brett N Anderson Albert M Ding Lina M Nilsson Kaoru Kusuma Veronika Tchesnokova Viola Vogel Evgeni V Sokurenko Wendy E Thomas

Bacterial adhesion to and subsequent colonization of surfaces are the first steps toward forming biofilms, which are a major concern for implanted medical devices and in many diseases. It has generally been assumed that strong irreversible adhesion is a necessary step for biofilm formation. However, some bacteria, such as Escherichia coli when binding to mannosylated surfaces via the adhesive p...

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