Abstract Background/Aims The intracellular chloride ion channel CLIC4 mediates the activation of cancer associated fibroblasts. Interestingly, systemic sclerosis (SSc) fibroblasts display a number similar properties to Tissue fibrosis in SSc is driven by active (myofibroblasts). Therefore this study we investigated role fibroblast activation. Methods Dermal were obtained from full thickness ski...

Skin’s natural capability to regenerate and rebuild itself is widely used in aesthetic cosmetology. The activity of dermal fibroblasts reduced with age, which leads the degradation collagen elastin. Additionally, proliferation ability diminishes, consequently affecting weakening cell regeneration processes. Tissue stimulation multiplication fibroblasts, protein synthesis production extracellula...

background: the regenerative capacity of the mammalian heart is quite limited. recent reports have focused on reprogramming mesenchymal stem cells into cardiomyocytes. we investigated whether fibroblasts could transdifferentiate into myocardium. methods: mouse embryonic fibroblasts were treated with trichostatin a (tsa) and 5-aza-2-deoxycytidine (5-aza-dc). the treated cells were permeabilized ...

Fibroblasts are the main cell type in dermis and major contributors to wound healing process. During skin development, papillary fibroblasts from upper uniquely give rise specialized hair follicle-supporting like dermal papillae, which controls development cycling, as well arrector pili muscles that grant its contractile functions. Neonatal also only supportive of follicle regeneration, we have...

introduction: the aims of this study were i) to define the chemical constituents of cuminum cyminum (cumin) essential oil, ii) to compare the antimicrobial activity of this oil to that of chlorhexidine (chx) and co-trimoxazole on planktonic and biofilm forms of bacteria isolated from the teeth with persistent endodontic infection and iii ) to compare the cytotoxicity of these medicaments on l92...

background: a lot of remedies, mostly plant based, were mentioned in the persian old pharmacopoeias for promoting of burn and wound healing and tissue repairing. the efficacy of most of these old remedies is unexplored till now. adiantum capillus‑veneris from adiantaceae family is one of them that was used to treating of some kinds of chronic wounds. methods: methanol extract was fractionated t...

  Objective: Different techniques have been suggested for the repair of bone defects at the injured sites. Use of biomembranes, or application of plasma rich in growth factor (PRGF) at the site of proliferation of osteoblasts are among the suggested techniques. The current study aimed to compare the biocompatibility of human periodontal ligament fibroblasts (hPLF) cultured on Hypro-Sorb F, Peri...

The promoting effect of doping multilayers hyaluronan and chitosan with metal ions on the adipogenic differentiation multipotent mouse fibroblasts.

Abstract Context Graves’ orbitopathy (GO) is an autoimmune disease that persists when immunosuppression achieved. Orbital fibroblasts from GO patients display peculiar phenotypes even if not exposed to autoimmunity, possibly reflecting genetic or epigenetic mechanisms, which we investigated here. Objective We aimed explore potential differences using primary cultures of orbital and control pati...

Secreted R-spondin (RSPO) proteins play a key role in reproductive organ development, epithelial stem cell renewal and cancer induction by reinforcing canonical Wnt signaling. We have previously reported that palmoplantar keratoderma (PPK), predisposition to cutaneous squamous carcinoma (SCC) development sex reversal segregate as autosomal recessive trait patients carrying RSPO1-mutations. Alth...