نتایج جستجو برای: fatty acid elongase gene

تعداد نتایج: 1796572  

Journal: :American journal of human genetics 2014
Eleonora Di Gregorio Barbara Borroni Elisa Giorgio Daniela Lacerenza Marta Ferrero Nicola Lo Buono Neftj Ragusa Cecilia Mancini Marion Gaussen Alessandro Calcia Nico Mitro Eriola Hoxha Isabella Mura Domenico A Coviello Young-Ah Moon Christelle Tesson Giovanna Vaula Philippe Couarch Laura Orsi Eleonora Duregon Mauro Giulio Papotti Jean-François Deleuze Jean Imbert Chiara Costanzi Alessandro Padovani Paola Giunti Marcel Maillet-Vioud Alexandra Durr Alexis Brice Filippo Tempia Ada Funaro Loredana Boccone Donatella Caruso Giovanni Stevanin Alfredo Brusco

Spinocerebellar ataxias (SCAs) are a heterogeneous group of autosomal-dominant neurodegenerative disorders involving the cerebellum and 23 different genes. We mapped SCA38 to a 56 Mb region on chromosome 6p in a SCA-affected Italian family by whole-genome linkage analysis. Targeted resequencing identified a single missense mutation (c.689G>T [p.Gly230Val]) in ELOVL5. Mutation screening of 456 i...

2013
Jun Zhang Yijuan Wei Bingfang Hu Min Huang Wen Xie Yonggong Zhai

The pregnane X receptor (PXR) was previously known as a xenobiotic receptor. Several recent studies suggested that PXR also played an important role in lipid homeostasis but the underlying mechanism remains to be clearly defined. In this study, we found that rifampicin, an agonist of human PXR, induced lipid accumulation in HepG2 cells. Lipid analysis showed the total cholesterol level increase...

Journal: :The Biochemical journal 2004
Suzette L Pereira Amanda E Leonard Yung-Sheng Huang Lu-Te Chuang Pradip Mukerji

Marine microalgae such as Pavlova and Isochrysis produce abundant amounts of the omega3-PUFAs (polyunsaturated fatty acids), EPA (eicosapentaenoic acid, 20:5n-3) and DHA (docosahexaenoic acid, 22:6n-3). The pathway leading to the conversion of EPA into DHA in these lower eukaryotes is not well established although it is predicted to involve an elongation step, catalysed by an elongating enzyme ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Antti Jula Jukka Marniemi Tapani Rönnemaa Arja Virtanen Risto Huupponen

OBJECTIVE To explore the separate and combined effects of simvastatin and a low-saturated diet rich in alpha-linolenic acid on serum fatty acids. METHODS AND RESULTS 120 hypercholesterolemic men were randomly allocated to a habitual diet or dietary treatment group and to receive, in random order, simvastatin 20 mg/d or placebo, each for 12 weeks, in a double-blind manner. Dietary treatment de...

2010
Sandeep J. Joseph Kelly R. Robbins Enrique Pavan Scott L. Pratt Susan K. Duckett Romdhane Rekaya

Conjugated linoleic acids (CLA) are of important nutritional and health benefit to human. Food products of animal origin are their major dietary source and their concentration increases with high concentrate diets fed to animals. To examine the effects of diet supplementation on the expression of genes related to lipid metabolism, 28 Angus steers were fed either pasture only, pasture with soybe...

2013
Emre Koyuncu John G. Purdy Joshua D. Rabinowitz Thomas Shenk

Human cytomegalovirus hijacks host cell metabolism, increasing the flux of carbon from glucose to malonyl-CoA, the committed precursor to fatty acid synthesis and elongation. Inhibition of acetyl-CoA carboxylase blocks the production of progeny virus. To probe further the role of fatty acid metabolism during infection, we performed an siRNA screen to identify host cell metabolic enzymes needed ...

2009
Kenji Tamura Asami Makino Françoise Hullin-Matsuda Toshihide Kobayashi Mutsuo Furihata Suyoun Chung Shingo Ashida Tsuneharu Miki Tomoaki Fujioka Taro Shuin Yusuke Nakamura Hidewaki Nakagawa

A number of epidemiologic studies have indicated a strong association between dietary fat intake and prostate cancer development, suggesting that lipid metabolism plays some important roles in prostate carcinogenesis and its progression. In this study, through our genome-wide gene expression analysis of clinical prostate cancer cells, we identified a novel lipogenic gene, ELOVL7 , coding a poss...

Journal: :Cancer Research 2021

Abstract The androgen receptor (AR) is the key oncogenic driver of prostate cancer, and despite implementation novel AR targeting therapies, outcomes for metastatic disease remain dismal. There an urgent need to better understand androgen-regulated cellular processes more effectively target dependence cancer cells through new therapeutic vulnerabilities. Transcriptomic studies have consistently...

2016
Peck Yean Tan Cheng Wei Chang Kaibo Duan Michael Poidinger Kai Lyn Ng Yap Seng Chong Peter D. Gluckman Walter Stünkel

Wharton's jelly-derived Mesenchymal Stem Cells (MSCs) isolated from newborns with intrauterine fetal growth restriction were previously shown to exert anabolic features including insulin hypersensitivity. Here, we extend these observations and demonstrate that MSCs from small for gestational age (SGA) individuals have decreased mitochondrial oxygen consumption rates. Comparing normally grown an...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید