Background and aims High blood pressure is the heritable risk factor for cardiovascular diseases. We investigated whether presence of familial genetic environmental factors are associated with increased high pressure.Methods A total 4,559 individuals from 401 families were included in this study. Familial aggregation analysis was carried out on systolic (SBP), diastolic (DBP), body mass index (...

Bilingual children's early lexical development so far has been part of the ongoing debate whether children start out with one system (Volterra & Taeschner 1978) or whether they develop two separate systems from early on (De Houwer 1990, Meisel 1994). In relation to bilingual children's lexical development, the debate has centred on the occurrence of cross-language synonyms or translation equiva...

We present numerical methods to solve the Israel– Stewart (IS) equations of causal relativistic dissipative fluid dynamics with bulk and shear viscosities. We then test these methods studying the Riemann problem in (1+ 1)and (2+ 1)-dimensional geometry. The numerical schemes investigated here are applicable to realistic (3 + 1)-dimensional modeling of a relativistic dissipative fluid. PACS 24.1...

Numerical simulations of planetesimal accretion in circumprimary and circumbinary orbits are described. The secular perturbations by the companion star and gas drag are included in our models. We derive limits on the parameters of the binary system for which accretion and then planetary formation are possible. In the circumbinary case we also outline the radial distance from the baricenter of t...

A Stewart Gough (SG) platform is a parallel manipulator consisting of a moving platform, which is connected via six Spherical-Prismatical-Spherical (SPS) legs with the base. Moreover a SG platform is called planar if the six platform anchor points mi (i = 1, . . . ,6) are located in a plane and if the corresponding base anchor points Mi are coplanar as well (see Fig. 1a). Note that a SG platfor...

Background: In India breast cancer incidence is on rise and large number of cases occur before 50 years age. Early diagnosis proper treatment are known to increase the survival patients. As fine needle aspiration cytology widely used as a preliminary mode for malignancies, adding reliable grading system in reporting shall aid planning management options.
 Methods: It’s prospective study do...

Received November 29, 2011, Revised May 3, 2012, Accepted for publication June 9, 2012 Corresponding author: Gyong Moon Kim, Department of Dermatology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 93 Jungbu-daero, Paldal-gu, Suwon 442-723, Korea. Tel: 82-31-249-7460, Fax: 82-31-242-8927, E-mail: gyongmoonkim@ catholic.ac.kr This is an Open Access article distri...

Background: Li-Fraumeni syndrome (LFS) is associated with germline TP53 mutations and a very high lifetime cancer risk. Algorithms that assess a patient's risk of inherited cancer predisposition are often used in clinical counseling. The existing LFS criteria have limitations, suggesting the need for an advanced prediction tool to support clinical decision making for TP53 mutation testing and L...

P53 is one of the most important tumor suppressor proteins in human cancers. Mutations in the TP53 gene are common features of malignant tumors and normally correlate to a more aggressive disease. In breast cancer, these gene alterations are present in approximately 20% of cases and are characteristically of missense type. In the present work we describe TP53 mutations in breast cancer biopsies...