An inhibitive assay of insecticides using Acetylcholinesterase (AChE) from the local fish Clarias batrachus is reported. AChE was assayed according to the modified method of Ellman. Screening of insecticide and heavy metals showed that carbofuran and carbaryl strongly inhibited C. batrachus AChE. The inhibition concentration (IC) IC50 values (and the 95% confidence interval) for both carbofuran...

Acetylcholinesterase enzyme (AChE) is the that catalyzes hydrolysis of neurotransmitter acetylcholine to choline. Inhibitors this (AChE-i) are used treat Alzheimer's, a neurodegenerative disease. Due side effects drugs used, there has been an increased interest in investigating inhibitory potentials natural products which presumed have fewer effects. For purpose, highland honey, chestnut royal ...

"Rheumatoid disease" in its acute or chronic form with systemic or local manifestations may simulate many diseases in general medicine. Local manifestations may resemble many specific arthritides and bony and muscular lesions with secondary joint involvement (Ellman, 1947; Ellman and Ball, 1948), and two cases of a chondro-osseous dystrophy, which had been regarded as an arthritic manifestation...

Alzheimer hastalığı (AH), zamanla beyin hücrelerinin ölümüne bağlı olarak bilişsel işlevlerde azalma, hafıza kaybı ve bunama ile ilişkilendirilmiştir. hastalığının tedavisinde sınırlayıcı uygulamaların mevcut oluşu, hastalığın sağlık harcamalarında kanser kalp hastalıklardan sonra dünyada üçüncü sırada oluşu araştırmacıları AH üzerinde erken evrede tanıma yeni tedavi yöntemlerine yönlendirmekte...

Objective(s): Methamphetamine (METH) is a powerful stimulant drug that directly affects the brain and induces neurological deficits. B12 is a water-soluble vitamin (vit) that is reported to attenuate neuronal degeneration. The goal of the present study is to investigate the effect of vitamin B12 on METH’s neurodegenerative changes.Materials and Methods: Two groups of 6 animals received METH (10...

Thiên niên kiện lá lớn đã được sử dụng trong y học cổ truyền từ lâu đời. Các đặc điểm vi phẫu và thành phần bột dược liệu của loài này vẫn chưa mô tả một cách toàn diện. Nghiên cứu phẫu, soi bột, đánh giá hoạt tính ức chế acetylcholinesterase chống oxy hoá lớn. bằng phương pháp kính hiển vi. Hoạt enzyme Ellman hóa thực hiện trên hình loại bỏ gốc tự do 2,2-diphenyl-1-picrylhydrazyl (DPPH). Đây l...

Bioactive compounds from plants play an important role in slowing many neurodegenerative diseases, such as Alzheimer’s disease, by inhibiting cholinesterase enzymes. Studies have shown that oxidative stress is associated with the development of disease. In traditional medicine Bosnia and Herzegovina, Teucrium montanum used to treat numerous diseases. The chemical composition biological activity...

background and objective: changes of the enzyme acetylcholinesterase are involved in pathogenesis of different nervous disorders including alzheimer’s disease. this research work was conducted to evaluate the inhibitory effect of pistacia lentiscus ethanolic extract on acetylcholinesterase activity. materials and methods: activity of the enzyme acetylcholinesterase (ache) was measured by ellman...

Objective(s): Alzheimer’s disease (AD) as progressive cognitive decline and the most common form of dementia is due to degeneration of the cholinergic neurons in the brain. Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. In the present study, we focused on the synthesis and anti-cholinesterase evaluation of n...

patients with alzheimer's disease have cognitive deficits, impaired long-term potentiation and learning and memory. a progressive reduction in cholinergic neurons in some areas of the brain such as cortex and hippocampus is related to the deficits in memory and cognitive function in alzheimer’s disease (ad). in the current project a new series of phthalimide derivatives were synthesized. p...