In Europe, mainly in the Mediterranean region, an intensive usage of pesticides was recorded during the past 30 years. According to information from agricultural cooperatives of the Mondego valley (Figueira da Foz, Portugal), Primextra(®) Gold TZ is the most used herbicide in corn crop fields and one of the 20 best-selling herbicides in Portugal. Copper is mainly used in pesticide formulations....

Araştırmada, Allium cepa L ve ferro glukonat (E579) kullanılmıştır. A. kökleri, farklı konsantrasyonlarda ile muamele edilmiştir. kök uzunlukları ölçülmüştür. Böylece EC50 değeri 0,068 g / l olarak belirlenmiştir. Daha sonra kökleri 24, 48, 72 saat 2 (0.034 l), (0.068 2XEC50 (0.136 l) Bu sürelerin sonunda uçları kesilerek ışık mikroskobunda gözlem için hazırlanmıştır. Her periyodu konsantrasyon...

BACKGROUND The pharmacokinetics and pharmacodynamics of an anesthetic drug may be influenced by gender. The purpose of this study was to compare effect-site half maximal effective concentrations (EC50) of propofol in male and female patients during i-gel insertion with dexmedetomidine 0.5 μg/kg without muscle relaxants. METHODS Forty patients, aged 20-46 years of ASA physical status I or II, ...

BACKGROUND In spite of its widespread clinical application, there is little information on the cellular cardiac effects of articaine. In the present study, the concentration-dependent effects of articaine on action potential morphology and the underlying ion currents were studied in isolated canine ventricular cardiomyocytes. METHODS Action potentials were recorded from the enzymatically disp...

In an attempt to identify potential new agents that are active against HIV-1, a series of novel pyridopyrimidine-5-carbohydrazide derivatives featuring a substituted benzylidene fragment were designed and synthesized based on the general pharmacophore of HIV-1 integrase inhibitors. The cytotoxicity profiles of these compounds showed no significant toxicity to human cells and they exhibited anti...

Drug resistance remains to be a serious problem with type I human immunodeficiency virus (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs). A series of novel boronic acid-containing diarylpyrimidine (DAPY) derivatives were designed via bioisosterism and scaffold-hopping strategies, taking advantage the ability acid group form multiple hydrogen bonds. The target compounds synthesi...

Nghiên cứu này nhằm mục đích tối ưu hóa điều kiện chiết xuất polyphenol và flavonoid từ lá sa kê. Để đạt được này, thiết kế Box-Behnken đã sử dụng để quy trình Ảnh hưởng của bốn yếu tố, bao gồm: tỷ lệ nguyên liệu/ dung môi, nồng độ ethanol, thời gian nhiệt siêu âm đến quá polyphenol, thực hiện. Kết quả cho thấy, là ở 15,98 phút, 69℃, liệu dung/ môi 1/30 (w/v) ethanol 69% với sự hỗ trợ sóng âm. ...

BACKGROUND Rind of Punica granatum is traditionally used in treatment of abdominal cramps and various GIT disorders. So far spasmolytic activity of rind of Punica granatum has been reported using in vitro model. However, its mode of action is not explored yet. Therefore, the current work describes the possible mode of action for spasmolytic activity of methanolic extract of rind of Punica grana...

The antioxidant activity in vitro of three poly(phenylacetyloxy)-substituted 1,1':4',1"-terphenyl compounds from the edible mushroom Thelephora ganbajun were investigated. The IC50 values of compounds 1-3 for lipid peroxidation in rat liver homogenate were 400, 48, 54 microM, respectively. Compounds 1-3 increased superoxide dismutase (SOD) activity with EC50 values of 182, 74, 204 microM. They ...

A functional high throughput screen identified a novel chemotype for the positive allosteric modulation (PAM) of the muscarinic acetylcholine receptor (mAChR) subtype 5 (M5). Application of rapid analog, iterative parallel synthesis efficiently optimized M5 potency to arrive at the most potent M5 PAMs prepared to date and provided tool compound 8n (ML380) demonstrating modest CNS penetration (h...