Excipients having self-assembling properties are less explored in the field of dry powder inhalation (DPI) technology. An amphiphilic lipopolymer system was developed using stearic acid (SA) and branched polyethyleneimine (BPEI) (1800 Dalton), at different proportions by covalent conjugation. A molecular dynamic (MD) simulation tool was employed for predicting the carrier behavior in a polar in...

In 1950, Frieden and Hisaw (2) described a method for the isolation of relaxin from the ovaries of pregnant sows. This method, which involved extraction of ground whole ovaries with 5 per cent aqueous SaCl, fractionation with ethanol, and finally precipitation with acetone, afforded good yields (200 to 250 GPU’ of relaxin per gm. of fresh tissue), and material of saCsfactory potency (30 to 90 G...

Administration of antibiotics by inhalation can greatly improve drug targeting to the site of respiratory infections. In addition, dry powder inhalers are particularly convenient for the patients. The purposes of this study were to demonstrate the interest of pulmonary temocillin delivery to reach high temocillin concentrations locally in the lungs as well as to prepare a spray-dried temocillin...

One of the advantages of dry influenza vaccines over conventional liquid influenza vaccines is that they can be used for alternative routes of administration. Previous studies showed that spray freeze-drying is an excellent technique to prepare vaccine containing powders for pulmonary delivery (J.P. Amorij, V. Saluja, A.H. Petersen, W.L.J. Hinrichs, A. Huckriede, H.W. Frijlink, Pulmonary delive...

We find that Mycobacterium smegmatis survives spray drying and retains cell viability in accelerated temperature stress (40 °C) conditions with a success rate that increases with increasing thermal, osmotic, and nutrient-restriction stresses applied to the mycobacterium prior to spray drying. M. smegmatis that are spray dried during log growth phase, where they suffer little or no nutrient-redu...

UNLABELLED Spray-dried monoclonal antibody (mAb) powders may offer applications more versatile than the freeze-dried cake, including preparing high-concentration formulations for subcutaneous administration. Published studies on this topic, however, are generally scarce. This study evaluates a pilot-scale spray dryer against a laboratory-scale dryer to spray-dry multiple mAbs in consideration o...

Two distinct drying methods (spouted bed and spray drying) were used for production of dried extracts of Bauhinia forficata Link (Leguminosae, Caesalpinoideae). High-quality powder products in terms of physical and chemical properties were obtained. HPLC fingerprints revealed that the chromatographic profiles of flavonoid compounds present in the dried extract did not change significantly, due ...

Cold pressed peel oil was added to high quality 50°Brix commercial orange concentrate and foam-mat dried, or diluted to single strength juice and freeze-dried using different platen temperatures. Amounts of peel oil ranged from 0.026% to 0.106% for samples to be foam-mat dried, and from 0.011% to 0.109% for freeze drying. For foam-mat drying, previously de veloped standard commercial conditions...

The avocado is a tropical fruit whose nutritional value is due mainly to its high lipid content. The aim of this work was to evaluate the rehydration of freeze-dried avocado (variety Collinson) powder and slices. The rehydration kinetics was determined using an experimental apparatus that monitored the volume of water absorbed by the sample with the time. Peleg and Weibull equations were used t...

this experiment was conducted to evaluate the effects of different levels of dried aerial parts powder and extract of tanacetum balasmita (tb) medicinal plant on performance, carcass traits and blood parameters of broilers. two hundred eighty ross-308 broilers from 10 to 42 days of age were used in a completely randomized design in 5 treatments and 4 replicates (14 birds per replicate). the tre...