UNLABELLED The HLA-DRB1 alleles encoding an amino acid sequence (QKRAA/QRRAA/RRRAA) at position 70 74 of the third hypervariable region of the β1 chain of the HLA-DRB1 gene, called shared epitope (SE), are associated with increased susceptibility to and severity of rheumatoid arthritis (RA) in different populations. OBJECTIVE To determine the frequency of HLA-DRB1 alleles in Brazilian patient...

BACKGROUND HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical features of adult onset Still's disease (AOSD) in a Japanese population by determining the DRB1 allele distributions. METHODS DRB1 genotyping of 96 patients with AOSD and 1,026 healthy controls was perfor...

OBJECTIVE Human leukocyte antigen (HLA) DRB1*04:36 is a low-frequency HLA-DRB1 allele. The aim here is to report the ethnicity of DRB1*04:36 and its associated HLA haplotypes among Taiwanese individuals. MATERIALS AND METHODS A sequence-based typing method was employed to confirm this low incidence allele. Polymerase chain reaction was performed to amplify exons 2 and 3 of the HLA-A and HLA-B...

A*0372 JMDP01K043 AB535153 Kenji Tadokoro, Tokyo, Japan A*0373 BY00578 GU256011 Carolyn K Hurley, Washington DC, USA A*0374 BY00575 GU256014 Carolyn K Hurley, Washington DC, USA A*2511 BY00577 GU256012 Carolyn K Hurley, Washington DC, USA A*300205 BY00580 GU256009 Carolyn K Hurley, Washington DC, USA A*3033 JMDP01K045 AB535154 Kenji Tadokoro, Tokyo, Japan A*3034 BY00564 GU138062 Carolyn K Hurle...

Two hundred Japanese panels were serologically typed for human leukocyte antigen (HLA) - DR to assign 65 HLA-DR8 haplotypes, which were then subdivided into two genotypes, i.e., DRB1*0802 and DRB1*0803, by a polymerase chain reaction (PCR)--based, simple, and practical method. The panels possessing DR8 specificity were firstly subjected to PCR with a couple of primers specifically to amplify th...

OBJECTIVE The protective effect of HLA-DRB1 alleles on the development of rheumatoid arthritis (RA) is poorly understood. The aim of this study was to perform a meta-analysis of 4 European populations to investigate which HLA-DRB1 alleles are associated with protection in anti-citrullinated protein antibody (ACPA)-positive RA and ACPA-negative RA. METHODS Data for >2,800 patients and >3,000 c...

Several studies have focused on polymorphisms of major histocompatibility complex (MHC) in sheep, Ovar-MHC. This molecule plays a pivotal role in antigen presentation for eliciting immune responses against invading pathogens. The best-characterized genetic control of disease resistance and immune response in animals is associated with MHC. Numerous molecular genetic investigations have been und...

Background: Anti-citrullinated protein antibody (ACPA) production is observed in several organs even prior to the onset of rheumatoid arthritis (RA), and oral mucosa considered be one important tissues. Saliva reflect microbiota(oralMB) including periodontal disease. A gene-environment interaction between cigarette smoking shared epitope genes HLA-DRB1*shared (SE) provides a high risk ACPA-posi...