In a previous paper (1) we reported on the utilization of intravenously injected salt before and after the injection of desoxycorticosterone acetate in normal individuals and in patients with Cushing's syndrome. It was pointed out that the injection of this steroid in normal individuals resulted in a decrease in the urinary excretion of sodium and chloride ions as compared to the control values...

Acknowledgements Many thanks to Doc. RNDr. Roman Barták, PhD. for patient and systematic guidance in creation of this Ph.D. thesis.

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The mechanism whereby the vasoconstrictor response to angiotensin II (AII) is influenced by sodium balance or disease is unclear. To explore this question, the renal vascular responses (RVR) to intrarenal injections of subpressor doses of AII and norepinephrine were studied in dogs with an electromagnetic flowmeter. Acute and chronic sodium depletion increased plasma renin activity (PRA) and bl...