BOTJLANGER and BISERrE (1) used a solution of acid acetone for the extraction of amino acids in biologic material. The separation of amino acids on buffered papers described by Ryb#{225}r, Touek, and Hais, (2) and Hais and Hordovs/q (3) used the combination of tertiary butanolborate buffer system (pH 8.5) for separation of amino acids on paper. In our laboratories we have developed a chromatogr...

5-Methoxysalicylic acid (MSA) is demonstrated to be a useful matrix for matrix-assisted laser desorption/ionization time-of-flight (TOF) mass spectrometry of oligonucleotides, when desorption/ionization without fragmentation is desired. When MSA is combined with the additive spermine, the need for desalting is reduced. The MSA/spermine matrix yields linear TOF mass spectra with improved resolut...