نتایج جستجو برای: dependent thioredoxin reductase

تعداد نتایج: 728251  

Journal: :Journal of vector borne diseases 2009
Amit Kumar Banerjee Neelima Arora U S N Murty

BACKGROUND Malaria, a scourge of mankind, imposes a huge socioeconomic burden in tropical countries. Emergence of multi-drug resistant malarial parasites impels us to explore novel drug targets. Thioredoxin reductase is a promising antimalarial drug target. METHODS The Thioredoxin reductase enzyme of Plasmodium falciparum was characterized in silico and protein disorder was predicted using av...

2012
Yuno Lee Songmi Kim Prettina Lazar Jeong Chan Moon Swan Hwang Sundarapandian Thangapandian Youngsik Shon Kyun Oh Lee Sang Yeol Lee Keun Woo Lee

2-Cys peroxiredoxins (Prxs) play important roles in the protection of chloroplast proteins from oxidative damage. Arabidopsis NADPH-dependent thioredoxin reductase isotype C (AtNTRC) was identified as efficient electron donor for chloroplastic 2-Cys Prx-A. There are three isotypes (A, B, and C) of thioredoxin reductase (TrxR) in Arabidopsis. AtNTRA contains only TrxR domain, but AtNTRC consists...

Journal: :The Journal of biological chemistry 1999
Q A Sun Y Wu F Zappacosta K T Jeang B J Lee D L Hatfield V N Gladyshev

The intracellular generation of reactive oxygen species, together with the thioredoxin and glutathione systems, is thought to participate in redox signaling in mammalian cells. The activity of thioredoxin is dependent on the redox status of thioredoxin reductase (TR), the activity of which in turn is dependent on a selenocysteine residue. Two mammalian TR isozymes (TR2 and TR3), in addition to ...

Journal: :The Journal of general virology 1988
A J Darling

In this study herpes simplex virus type 1-encoded ribonucleotide reductase was shown to be able to utilize thioredoxin purified from the cyanobacterium Anabaena variabilis as a hydrogen donor for the enzyme. An assay has been developed to search for proteins which can function as a hydrogen donor for the viral ribonucleotide reductase. A protein has been identified and purified to homogeneity f...

Journal: :Journal of biochemistry 2008
Muneaki Takahata Takashi Tamura Katsumasa Abe Hisaaki Mihara Suguru Kurokawa Yoshihiro Yamamoto Ryuhei Nakano Nobuyoshi Esaki Kenji Inagaki

Escherichia coli growing under anaerobic conditions produce H(2) and CO(2) by the enzymatic cleavage of formate that is produced from pyruvate at the end of glycolysis. Selenium is an integral part of formate dehydrogenase H (FDH H), which catalyses the first step in the formate hydrogen lyase (FHL) system. The genes of FHL system are transcribed only under anaerobic conditions, in the presence...

Journal: :Biochemistry 2012
Olof Björnberg Kenji Maeda Birte Svensson Per Hägglund

Thioredoxin reduces disulfide bonds, thus regulating activities of target proteins in various biological systems, e.g., inactivation of inhibitors of starch hydrolases and proteases in germinating plant seeds. In the three-dimensional structure of a complex with barley α-amylase/subtilisin inhibitor (BASI), two loops in barley thioredoxin h2 (HvTrxh2), containing an invariant cis-proline ((86)E...

Journal: :Molecular pharmacology 2009
Chao Yan Biehuoy Shieh Philip Reigan Zhiyong Zhang Marie A Colucci Aurélie Chilloux Jeffery J Newsome David Siegel Dan Chan Christopher J Moody David Ross

The indolequinone ES936 {5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione} was previously developed in our lab as an antitumor agent against pancreatic cancer. The objective of this study was to identify indolequinones with improved potency against pancreatic cancer and to define their mechanisms of action. Pancreatic cancer cell lines PANC-1, MIA PaCa-2, and BxPC-3 were used i...

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