how to cite this article: inaloo s, haghbin s, moradi m, dashti h, safari n. acquired cns demyelinating syndrome in children referred to shiraz pediatric neurology ward. iran j child neurol. 2014 spring; 8(2):18-23. objective incidence of cns acquired demyelinating syndrome (ads), especially multiple sclerosis (ms) in children, appears to be on the rise worldwide. the objective of this study wa...

Substantial evidence indicates that stress can precipitate or worsen symptoms of inflammation in general and more specifically in multiple sclerosis (MS), a demyelinating, autoimmune disease characterized by inflammation of the central nervous system (CNS). However, the mechanism of how stress affects MS is not well understood. We reviewed publications in PubMed since 1995 and propose that neur...

Abstract Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system. MS three times more common in women, yet severe men. The mechanisms underlying these sex differences remain largely unknown. initiated by autoreactive T cells, but CNS-infiltrating myeloid cells are key effector driving pathology. role CNS-resident microglial less clear. We have previously sho...

TRPM2, a highly Ca(2+)-permeable member of the transient receptor potential melastatin-related (TRPM) family of cation channels, is expressed in cells of the immune system. We demonstrate firstly that TRPM2 cation channels on T cells critically influence T cell proliferation and proinflammatory cytokine secretion following polyclonal T cell receptor stimulation. Consistently, trpm2-deficient mi...

BACKGROUND Neuromyelitis Optica (NMO) is an inflammatory demyelinating disease of the CNS. There have been few epidemiologic studies on NMO, none in Portugal. OBJECTIVE To analyze the clinical, biological and MRI characteristics from a cohort of Portuguese patients who fulfilled the Wingerchuk 2006 NMO/NMOSD criteria. To identify and characterize those who had concomitant autoimmune disease o...

Susac syndrome (SuS) is a rare autoimmune micro-angiopathic endotheliopathy. The diagnosis of SuS challenge to neurologists because the diversity symptoms and rarity occurrence classical triad SuS. In this context, plethora immunological/demyelinating disorders can mimic features neurological manifestations detection snowball corpus callosal lesion unique A high degree suspicion key early immun...

Angiogenesis, or the growth of new blood vessels from existing vasculature, is critical for the proper development of many organs. This process is inhibited and tightly regulated in adults, once endothelial cells have acquired organ-specific properties. Within the central nervous system (CNS), angiogenesis and acquisition of blood-brain barrier (BBB) properties by endothelial cells is essential...

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system (CNS) and can be induced by inoculation of animals with homogenized CNS tissue or highly purified myelin proteins such as myelin basic protein (MBP) or proteolipid protein (PLP). It is widely studied as a possible animal model of multiple sclerosis. We performed the present neu...