introduction acute disseminated encephalomyelitis (adem) is an acute inflammatory and demyelinating disease of the central nervous system, resulting in various neurological symptoms. usually, the disease appears following vaccination or systemic viral infections. in rare cases, the disease appears following pneumococcal infections. case presentation the patient was a 27 year-old man who was ref...

Allergic and autoimmune diseases have been considered to be at the opposite sides of the spectrum of the immune response. Autoimmune diseases, such as multiple sclerosis (MS), rheumatoid arthritis and type 1 insulin-dependent diabetes mellitus, are considered T helper 1 (Th1)-mediated diseases, and allergic disorders, such as asthma, food allergy or rhinitis, are considered to be Th2-mediated. ...

Extensive research over the last decades basically failed to identify a common cause of noninfectious inflammatory central nervous system (CNS) demyelinating disease. To a great extent, this may reflect that the group of inflammatory CNS demyelinating disorders likely contains multiple pathogenetically distinct disease entities. Indeed, the greatest success so far in deciphering the pathogenesi...

Multiple sclerosis is a demyelinating disorder of the central nervous system (CNS), in which an immune attack directed against myelin constituents causes myelin destruction and death of oligodendrocytes, the myelin-producing cells. Here, the efficacy of nerve growth factor (NGF), a growth factor for neurons and oligodendrocytes, in promoting myelin repair was evaluated using the demyelinating m...

The discovery of novel autoantibodies in neurological disorders contributes to a better understanding its pathogenesis, improves the accuracy diagnosis, and leads new treatment strategies. Advances techniques for screening detection have enabled antibodies central nervous system (CNS) neuromuscular diseases. Cell-based assays using live or fixed cells overexpressing target antigens are widely u...

Many disorders of the CNS, such as multiple sclerosis (MS), are characterized by the loss of the myelin sheath surrounding nerve axons. MS is associated with infiltration of inflammatory cells into the brain and spinal cord, which may be the primary cause of demyelination or which may be induced secondary to axonal damage. Both the innate and adaptive arms of the immune system have been reporte...

Background: Idiopathic longitudinally extensive transverse myelitis is defined as a focal spinal cord lesion that involves three or more segments of the shown by neuroimaging, and results in profound disability. The clinical picture patient with idiopathic advanced often dramatic may consist paraparesis tetraparesis, sensory disturbances, pelvic dysfunction. common manifestation neuromyelitis o...

SLE (systemic lupus erythematosus) is a multisystem autoimmune disorder of unknown aetiology which can present with myriad clinical presentation. The neurological manifestations of SLE consist of central nervous system (CNS) and peripheral nervous system manifestations (PNS). The CNS manifestations are aseptic meningitis, cerebrovascular accidents (stroke), demyelinating disorders, headache, in...

Acute myelitis represents a major subset of acute non-compressive myelopathies. Acute non-compressive myelopathies include vascular, infectious, autoimmune, inflammatory, neoplastic and metastatic disorders. Acute myelitis can occur as an isolated inflammatory disorder, or as part of a multifocal CNS demyelinating disease such as acute disseminated encephalomyelitis, multiple sclerosis, neuromy...

Myelin oligodendrocyte glycoprotein immunoglobulin G (anti-MOG-IgG) has been recently found to be associated with some forms of idiopathic inflammatory demyelinating CNS disorders. In a preliminary study from India, recurrent optic neuritis and isolated longitudinally extensive transverse myelitis were identified as the common phenotypes. The clinical and radiologic features of this newly disco...